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Table 1 Case study p-values for SNPs flanking the causal loci

From: One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies

 

p-Value (relative rank)

SNP index

185

186

191

192

CMMT

4.0 × 10-2 (457)

8.3 × 10-5 (1)

1.2 × 10-1 (1257)

2.6 × 10-3 (43)

FBAT

9.9 × 10-5 (2)

2.4 × 10-3 (30)

4.4 × 10-4 (5)

5.4 × 10-3 (57)

2-stagea

1.0

2.4 × 10-3 (1)

1.0

1.0

1-stage CSST

6.2 × 10-5 (3)

4.3 × 10-6 (1)

6.1 × 10-4 (16)

2.2 × 10-4 (7)

1-stage CLRT

8.0 × 10-5 (3)

7.7 × 10-6 (1)

6.9 × 10-4 (13)

3.0 × 10-4 (5)

  1. aIf a SNP is not among the top ten SNPs from the CMMT stage, it is not considered in the second stage, so the two-stage method p-value is listed as 1.0, the only p-value for which the null hypothesis will never be rejected, regardless of α.
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BMC Proceedings

ISSN: 1753-6561

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