From: Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population
Pr(g1, g2)
(g1, g2)
Assume HWE
Allow departure from HWE
(0, 0)
q 4 + p q 3 + 1 4 p 2 q 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGXbqCdaahaaWcbeqaaiabisda0aaakiabgUcaRiabdchaWjabdghaXnaaCaaaleqabaGaeG4mamdaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiCaa3aaWbaaSqabeaacqaIYaGmaaGccqWGXbqCdaahaaWcbeqaaiabikdaYaaaaaa@3C19@
P 0 2 + 1 2 P 0 P 1 + 1 16 P 1 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGqbaudaqhaaWcbaGaeGimaadabaGaeGOmaidaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaIYaGmaaGaemiuaa1aaSbaaSqaaiabicdaWaqabaGccqWGqbaudaWgaaWcbaGaeGymaedabeaakiabgUcaRmaalaaabaGaeGymaedabaGaeGymaeJaeGOnaydaaiabdcfaqnaaDaaaleaacqaIXaqmaeaacqaIYaGmaaaaaa@3E60@
(0, 1)
pq2(1 + q)
P 0 P 1 + 1 4 P 1 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiuaa1aa0baaSqaaiabigdaXaqaaiabikdaYaaaaaa@3758@
(0, 2)
1 2 p 2 q 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabikdaYaaacqWGWbaCdaahaaWcbeqaaiabikdaYaaakiabdghaXnaaCaaaleqabaGaeGOmaidaaaaa@33BA@
1 8 P 1 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabiIda4aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaaaa@31E2@
(1, 1)
pq(1 + pq)
1 2 P 0 P 1 + 1 4 P 1 2 + 1 2 P 1 P 2 + 2 P 0 P 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabikdaYaaacqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiuaa1aa0baaSqaaiabigdaXaqaaiabikdaYaaakiabgUcaRmaalaaabaGaeGymaedabaGaeGOmaidaaiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaemiuaa1aaSbaaSqaaiabikdaYaqabaGccqGHRaWkcqaIYaGmcqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIYaGmaeqaaaaa@4730@
(1, 2)
p2q(1 + p)
1 4 P 1 2 + P 1 P 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabisda0aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaOGaey4kaSIaemiuaa1aaSbaaSqaaiabigdaXaqabaGccqWGqbaudaWgaaWcbaGaeGOmaidabeaaaaa@375C@
(2, 2)
1 4 p 2 q 2 + p 3 q + p 4 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabisda0aaacqWGWbaCdaahaaWcbeqaaiabikdaYaaakiabdghaXnaaCaaaleqabaGaeGOmaidaaOGaey4kaSIaemiCaa3aaWbaaSqabeaacqaIZaWmaaGccqWGXbqCcqGHRaWkcqWGWbaCdaahaaWcbeqaaiabisda0aaaaaa@3C17@
1 16 P 1 2 + 1 2 P 1 P 2 + P 2 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabigdaXiabiAda2aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaIYaGmaaGaemiuaa1aaSbaaSqaaiabigdaXaqabaGccqWGqbaudaWgaaWcbaGaeGOmaidabeaakiabgUcaRiabdcfaqnaaDaaaleaacqaIYaGmaeaacqaIYaGmaaaaaa@3E68@