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Table 1 Single-marker analysis for SNPs in PTPN22

From: Case-control association analysis of rheumatoid arthritis with candidate genes using related cases

  

Minor Allele Frequencies

p-valuesa

  

Cases

Controls

  

SNP

dbSNP ID

Affected Siblingb (n = 1256)

One Sibling per Familyc (n = 664)

(n = 1519)

Affected Siblingb

One Sibling per Familyc

1

rs3789604

0.198

0.199

0.179

0.10251

0.11214

2d

rs3811021

0.199

0.200

0.179

0.0978

0.10504

3

rs1217413

0.269

0.267

0.217

7 × 10-5

0.00039

4d

Ss38346942

0.015

0.015

0.013

0.68537

0.63067

5

rs1217388

0.292

0.293

0.251

0.00233

0.00436

6

Ss38346943

0.017

0.020

0.027

0.03122

0.13409

7

rs1310182

0.491

0.495

0.430

5 × 10-5

7 × 10-5

8d

Ss38346944

0.03

0.031

0.023

0.19819

0.15854

9d

rs2476601

0.154

0.160

0.084

4.32 × 10-13

8.53 × 10-13

10

rs12730735

0.268

0.270

0.295

0.04785

0.09262

11d

rs11102685

0.091

0.085

0.076

0.0629

0.32266

12

rs12760457

0.267

0.269

0.294

0.04884

0.09406

13

rs2488458

0.292

0.293

0.252

0.00257

0.00472

14d

rs1217414

0.243

0.236

0.276

0.01283

0.00526

  1. ap-Values were not adjusted for the multiple testing.
  2. bAllele frequencies and p-values were obtained using all cases and unrelated controls.
  3. cAllele frequencies and p-values obtained using one randomly selected case per family and unrelated controls.
  4. dSNPs selected from the stepwise regression.
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BMC Proceedings

ISSN: 1753-6561

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