Figure 2

Knockdown of h NAA10 of the hNatA complex leads to apoptosis and cell cycle arrest. Knockdown of hNAA10 leads to reduced acetylation of hNaa10p subtrates [9]. As a direct or indirect effect of this, apoptosis and cell cycle arrest is observed [8]. Direct acetylation of β-catenin has been implicated in the cell cycle arrest mediated by hNAA10 knockdown [35]. Loss of acetylation can lead to reduced Cyclin D1 expression, and subsequent cell cycle arrest in the in the G₀-G₁ phase. One hypothetical mechanism is that hNatA affects cell cycle indirectly via a HAT (Histone Acetyltransferase), acting on β-catenin or directly or indirectly at the level of Cyclin D1 expression. This is more thoroughly issued in a previous publication [40]. More experimental studies are needed to determine the mechanisms through which hNatA knockdown phenotypes are formed.