Table 1 SNPs associated significantly with the qualitative MetS corrected for medication use (4 exams of offspring cohort and 1 exam of generation 3 cohort data)
| Â | Â | Â | Â | Â | Â | Exam 21a | Exam 23 | Exam 25 | Exam 27 | Exam 31 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker  | Chr | Position (bp) | Hugo | Role | MAF (%) | Estimate  | STD error | χ2 p-value | Estimate  | STD error | χ2 p-value | Estimate  | STD error | χ2 p-value | Estimate  | STD error | χ2 p-value | Estimate  | STD error | χ2 p-value |
50 k | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs17390167        | 1 | 3084691 | PRDM16 | Intron | 5.2 | -0.01 | 0.02 | 4.9 × 10-1 | -0.06 | 0.03 | 1.8 × 10 -2 | -0.14 | 0.03 | 3.8 × 10 -6 | -0.04 | 0.03 | 1.4 × 10-1 | -0.01 | 0.02 | 4.6 × 10-1 |
rs11508026        | 16 | 55556829    | CETP | Intron | 42.5 | -0.02 | 0.01 | 1.1 × 10-1 | -0.04 | 0.01 | 2.0 × 10 -4 | -0.04 | 0.01 | 2.7 × 10 -3 | -0.07 | 0.01 | 7.2 × 10 -7 | -0.01 | 0.01 | 1.6 × 10-1 |
500 k (in genes) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs13241465        | 7 | 33473074 | PTHB1 | Intron | 32.6 | 0.00 | 0.01 | 8.8 × 10-1 | 0.02 | 0.01 | 1.8 × 10-1 | 0.08 | 0.01 | 1.4 × 10 -8 | 0.03 | 0.01 | 1.3 × 10 -2 | 0.03 | 0.01 | 1.3 × 10 -3 |
rs4236337        | 7 | 33473431 | PTHB1 | Intron | 32.4 | 0.00 | 0.01 | 9.2 × 10-1 | 0.02 | 0.01 | 1.6 × 10-1 | 0.08 | 0.01 | 2.8 × 10 -8 | 0.03 | 0.01 | 1.9 × 10 -2 | 0.03 | 0.01 | 2.4 × 10 -3 |
rs4509212        | 7 | 33473170 | PTHB1 | Intron | 31.4 | 0.00 | 0.01 | 9.4 × 10-1 | 0.02 | 0.01 | 7.2 × 10-2 | 0.07 | 0.01 | 6.2 × 10 -8 | 0.03 | 0.01 | 1.5 × 10 -2 | 0.02 | 0.01 | 1.3 × 10 -2 |
rs2418441        | 9 | 118114658 | PAPPA | Intron | 1.0 | -0.02 | 0.04 | 6.7 × 10-1 | 0.01 | 0.05 | 8.4 × 10-1 | 0.06 | 0.06 | 3.3 × 10-1 | -0.03 | 0.06 | 5.9 × 10-1 | -0.25 | 0.04 | 1.2 × 10 -8 |
rs10408896        | 19 | 8124201 | FBN3 | Promoter | 0.1 | 0.03 | 0.14 | 8.3 × 10-1 | 0.41 | 0.16 | 1.0 × 10 -2 | 0.12 | 0.19 | 5.4 × 10-1 | 0.12 | 0.19 | 5.4 × 10-1 | 0.49 | 0.09 | 8.8 × 10 -8 |
500 k (not in genes) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
rs318256        | 8 |  |  |  | 8.2 | -0.01 | 0.02 | 4.6 × 10-1 | 0.00 | 0.02 | 9.2 × 10-1 | 0.02 | 0.02 | 4.4 × 10-1 | 0.01 | 0.02 | 7.2 × 10-1 | 0.08 | 0.01 | 1.5 × 10 -7 |
rs1431573        | 11 | 126981969 |  |  | 43.9 | -0.01 | 0.01 | 5.5 × 10-1 | -0.06 | 0.01 | 1.4 × 10- 7c | -0.03 | 0.01 | 7.8 × 10 -3 | -0.02 | 0.01 | 1.9 × 10-1 | 0.00 | 0.01 | 9.4 × 10 -1 |
rs17037068        | 12 | 104333075 |  |  | 1.7 | 0.10 | 0.04 | 3.7 × 10 -3b | 0.27 | 0.04 | 5.3 × 10 -10 | 0.14 | 0.05 | 9.1 × 10 -3 | 0.14 | 0.05 | 4.2 × 10 -3 | -0.03 | 0.03 | 2.9 × 10-1 |
rs12437159        | 14 | 45882211 |  |  | 44.6 | -0.02 | 0.01 | 6.7 × 10 -3 | -0.04 | 0.01 | 6.2 × 10 -5 | -0.06 | 0.01 | 4.3 × 10 -7 | -0.08 | 0.01 | 1.0 × 10 -9 | 0.00 | 0.01 | 9.1 × 10-1 |
rs12147964        | 14 | 45888772 |  |  | 42.5 | -0.02 | 0.01 | 9.8 × 10 -3 | -0.04 | 0.01 | 2.7 × 10 -4 | -0.07 | 0.01 | 2.7 × 10 -8 | -0.08 | 0.01 | 7.7 × 10 -11 | 0.00 | 0.01 | 8.6 × 10-1 |
rs2899976        | 14 | 45893237 |  |  | 41.8 | -0.02 | 0.01 | 1.3 × 10 -2 | -0.04 | 0.01 | 9.5 × 10 -4 | -0.07 | 0.01 | 2.0 × 10 -7 | -0.08 | 0.01 | 2.3 × 10 -10 | 0.00 | 0.01 | 9.1 × 10-1 |
rs11625735        | 14 | 45895075 |  |  | 41.8 | -0.02 | 0.01 | 1.4 × 10 -2 | -0.04 | 0.01 | 4.7 × 10 -4 | -0.07 | 0.01 | 9.4 × 10 -8 | -0.08 | 0.01 | 1.8 × 10 -10 | 0.00 | 0.01 | 9.0 × 10-1 |
rs2010338        | 14 | 45895631 |  |  | 41.8 | -0.02 | 0.01 | 8.9 × 10 -3 | -0.04 | 0.01 | 3.4 × 10 -4 | -0.07 | 0.01 | 4.2 × 10 -8 | -0.08 | 0.01 | 1.5 × 10 -10 | 0.00 | 0.01 | 7.4 × 10-1 |
rs2415974        | 14 | 45906862 |  |  | 42.0 | -0.02 | 0.01 | 7.1 × 10 -3 | -0.04 | 0.01 | 3.0 × 10 -4 | -0.07 | 0.01 | 1.2 × 10 -7 | -0.08 | 0.01 | 6.8 × 10 -11 | 0.00 | 0.01 | 7.8 × 10-1 |
rs8009432        | 14 | 45917176 |  |  | 41.7 | -0.02 | 0.01 | 1.4 × 10 -2 | -0.04 | 0.01 | 4.4 × 10 -4 | -0.07 | 0.01 | 1.2 × 10 -7 | -0.08 | 0.01 | 3.1 × 10 -10 | 0.00 | 0.01 | 8.6 × 10-1 |
rs10498398        | 14 | 45937239 |  |  | 41.1 | 0.02 | 0.01 | 9.8 × 10 -3 | 0.04 | 0.01 | 1.0 × 10 -3 | 0.07 | 0.01 | 8.6 × 10 -8 | 0.08 | 0.01 | 1.7 × 10 -9 | 0.00 | 0.01 | 8.4 × 10-1 |
rs8019899        | 14 | 45952022 |  |  | 41.3 | 0.02 | 0.01 | 5.6 × 10 -3 | 0.04 | 0.01 | 1.1 × 10 -3 | 0.07 | 0.01 | 1.2 × 10 -7 | 0.07 | 0.01 | 3.0 × 10 -9 | 0.00 | 0.01 | 8.1 × 10-1 |