Genetic association studies and the effect of misclassification and selection bias in putative confounders

BMC Proceedings

Table 3 Effect of differential misclassification of smoking status on the rs12565497-MI association

% Misclassified				Average bias
MI smokers	MI non-smokers	No MI smokers	No MI non-smokers	Estimate	SE	Range	% Biased toward null
"Truth" (Assumes 0% misclassification)				0.3889 ^a	0.1111 ^a	-	-
15	5	10	2	-0.002	0.000	0.367-0.408	65.0
20	10	15	2	-0.001	0.000	0.360-0.421	56.6
25	15	20	2	-0.001	0.001	0.349-0.447	51.4
30	20	25	2	0.000	0.002	0.332-0.451	51.2

ISSN: 1753-6561