Figure 1
Association results for Visit 3 LDL on chromosome 22. Within each panel the vertical axis is -log10(p) for the association test and the horizontal axis represents the SNP markers (numbered sequentially). Panels on the top row (left to right) are ignore medication use, delete medicated subjects, and medication (Y/N) covariate. Panels on the bottom row are (left to right) corrections based on clinical trials data, the simulation procedure, and an over-correction. The dotted reference line represents the "true" -log(p) at the disease locus (RS2294207), with locus-specific heritabilities at the disease locus shown in each panel.