Table 1 Analysis variables, corrections and total heritabilities
LDL-c | Heritabilities | |||
|---|---|---|---|---|
Scheme | Method of adjustment | Correction | Visit 1 | Visit 3 |
1 | No correction, ignore medication status | None | 43.8% | 25.2% |
2 | No correction, assign medicated values as missing | None | 44.3% | 33.5% |
3 | No correction, treat medication (Y/N) as covariate | (Covariate) | 43.6% | 30.1% |
4 | Use clinical trials data to correct LDLa | X + 48.1 mg/dl | 46.6% | 47.9% |
5 | Use GAW16 simulation protocol to correct LDLb | X/(1 - 0.3) | 46.6% | 50.1% |
6 | Over-correct LDL (1) | X + 75 mg/dl | 46.6% | 50.0% |
7 | Over-correct LDL (2) | X + 100 mg/dl | 45.7% | 48.5% |