Classification tree for detection of single-nucleotide polymorphism (SNP)-by-SNP interactions related to heart disease: Framingham Heart Study

Table 2 Functions of 16 SNPs that determined the splits in the classification tree

SNP	Alleles	MAF^b	Chromosome	Position	Gene	Function	p-value^c
rs2741302	A^a/C	0.179582	2	232,936,077			0.0245
rs41009	A^a/G	0.134071	2	8,012,609			0.0009
rs10023987	C^a/T	0.196187	4	98,109,876			0.0068
rs10804990	A/G^a	0.381304	4	6,970,562	TBC1D14 TBC1 domain family member 14	intron	0.0253
rs1417507	T^a/C	0.276753	6	50,324,791			0.0146
rs2146333	A^a/C	0.188192	6	36,564,996	KCTD20 potassium channel tetramerization domain containing 20	3'UTR	0.01703
rs9275765	A^a/T	0.215867	6	32,797,302
rs2191806	C^a/G	0.182042	7	78,581,862	MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2	intron	0.0169
rs17517421	A^a/G	0.113776	8	18,410,095			0.0007
rs10833833	A^a/G	0.123616	11	3,355,238	ZNF195 zinc finger protein 195	intron	0.0092
rs1894035	C^a/T	0.311808	12	50,932,021	KRT86 keratin 86	intron	0.02598
rs7955732	G^a/T	0.403444	12	71,011,262	TRHDE thyrotropin-releasing hormone degrading enzyme	intron	0.02056
rs8011590	C^a/G	0.083025	14	106,109,086			0.01665
rs9924619	C^a/G	0.115006	16	28,924,029			0.00072
rs17763533	C^a/T	0.214637	17	41,273,970			0.01929
rs2212596	A^a/C	0.49754	21	38,890,404	ERG v-ets erythroblastosis virus E26 oncogene homolog (avian)	intron	0.01421

ISSN: 1753-6561