Table 2 Summary of single-SNP tests of association: SNPs demonstrating strong evidence of association (p < 1 × 10-5) of association with RA in the sex-differentiated analysis, not identified in the combined sex analysis
From: Assessment of sex-specific effects in a genome-wide association study of rheumatoid arthritis
SNP | Chromosome | Location (Mb) | MAF | Combined sexes test | Allelic OR (95% CI) | Sex-differentiated test p-value | Sex interaction test p-value | ||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | p-value | Allelic OR (95% CI)a | Females | Males | Â | Â |
rs7371994 | 3 | 54.57 | 0.289 | 5.30 × 10-1 | 1.06 (0.88-1.28) | 0.76 (0.60-0.95) | 2.36 (1.62-3.41) | 5.09 × 10-7 | 1.68 × 10-7 |
rs12412942 | 10 | 2.35 | 0.403 | 1.91 × 10-1 | 1.13 (0.94-1.34) | 1.47 (1.19-1.81) | 0.53 (0.37-0.76) | 1.49 × 10-6 | 7.08 × 10-7 |
rs17740690 | 11 | 122.90 | 0.065 | 3.43 × 10-5 | 2.19 (1.51-3.17) | 1.65 (1.08-2.51) | 5.33 (2.40-11.87) | 4.63 × 10-6 | 1.13 × 10-2 |