Table 3 Summary of single-SNP tests of association: SNPs demonstrating strong evidence of sex interaction (p < 1 × 10-5), not identified in the combined sex or sex-differentiated analyses
From: Assessment of sex-specific effects in a genome-wide association study of rheumatoid arthritis
SNP | Chromosome | Location (Mb) | MAF | Combined sexes test | Allelic OR (95% CI) | Sex-differentiated test p-value | Sex interaction test p-value | ||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | p-value | Allelic OR (95% CI) | Females | Males | Â | Â |
rs3798014 | 5 | 9.49 | 0.398 | 5.45 × 10-1 | 1.05 (0.89-1.25) | 1.38 (1.12-1.71) | 0.56 (0.40-0.78) | 1.50 × 10-5 | 3.98 × 10-6 |
rs7068778 | 10 | 95.01 | 0.167 | 6.17 × 10-1 | 1.06 (0.84-1.33) | 0.77 (0.59-1.00) | 2.80 (1.71-4.56) | 2.07 × 10-5 | 5.24 × 10-6 |
rs33149 | 12 | 30.87 | 0.262 | 4.03 × 10-1 | 1.08 (0.90-1.31) | 1.42 (1.13-1.78) | 0.53 (0.36-0.77) | 2.87 × 10-5 | 9.21 × 10-6 |
rs2699089 | 12 | 126.93 | 0.085 | 1.89 × 10-1 | 1.23 (0.90-1.66) | 0.84 (0.59-1.19) | 5.15(2.54-10.44) | 1.20 × 10-5 | 6.03 × 10-6 |
rs677295 | 18 | 57.91 | 0.260 | 8.78 × 10-1 | 1.02 (0.83-1.24) | 0.76 (0.60-0.96) | 2.28 (1.51-3.43) | 3.69 × 10-5 | 9.21 × 10-6 |