Volume 4 Supplement 2
A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapy
© Sobral et al; licensee BioMed Central Ltd. 2010
Published: 24 September 2010
The synthesized compound showed considerably enhanced photostability compared with the parent T(OH)PP (photodegradation quantum yield 4.65 × 10-4). The photosensitizer triplet state is normally considered to be essential for PDT, and to lead to the formation of cytotoxic oxygen species [5, 6]. The lifetimes and quantum yields of the triplet state of T(NAF)PP were evaluated and presented typical values for this type of compounds. The quenching rate constant by molecular oxygen and singlet oxygen yield were also determined. The photodynamic effect in human carcinoma HT-29 cells was evaluated, and this novel porphyrin showed good properties as a sensitizer in photodynamic therapy with an in vitro cytotoxicity IC50 value of 6.80 μg mL-1 for 24 h incubation.
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