Volume 4 Supplement 2
Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?
© Dias et al; licensee BioMed Central Ltd. 2010
Published: 24 September 2010
Melanoma is a highly metastatic tumour and its incidence has ranked 5th and 6th among the most common cancer afflicting both men and women. Melanoma cells have a diminished antioxidant potential compared to normal melanocytes, which leads to an accumulation of ROS . 1,4-benzopyrone heterocyclic compounds are widely distributed in plants and are reported to exhibit several biological roles, including antioxidant and free radical scavenging , displaying a variety of pharmacological properties such as anti-inflammatory and antitumour . The present study aimed to assess the response of the melanotic human skin melanoma (A375) cell line to treatment with 8 different benzopyran derivatives (eg. fisetin, luteolin and quercetin) - in the concentration range 12.5 - 100µM, for 24, 48 and 72h incubation periods (using the MTT assay). Reversibility of the drug effect (after 3 days) was also tested. Concomitantly, similar experiments were carried out for non-neoplasic, non-immortalised, human foreskin fibroblasts (BJ).
The results thus gathered allowed to conclude that the chromone derivatives are promising chemopreventive and/or chemotherapeutic agents towards melanoma, while having no considerable adverse effect against healthy cells.
- Yang Z, Yang S, Misner BJ, Chiu R, Liu F, Meyskens FL: Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol. Mol Cancer Ther. 2008, 7: 3751-3760. 10.1158/1535-7163.MCT-08-0562.View ArticlePubMedGoogle Scholar
- Okawa M, Kinjo J, Nohara T, Ono M: DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants. Biol Pharm Bull. 2001, 24: 1202-1205. 10.1248/bpb.24.1202.View ArticlePubMedGoogle Scholar
- Pietta PG: Flavonoids as Antioxidants. J Nat Prod. 2000, 63: 1035-1042. 10.1021/np9904509.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.