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Table 2 The number of enriched Go-categories are counted over all 24 clusters at a false discovery rate of 0.05 which is the default configuration of GoMiner. k-means and PCA+k-means do not show any eye specific enrichement in any of the clusters. Only LE+k-means provides one cluster that is enriched for 3 categories specific to eye development. These categories would have even been picked at an FDR of 0.01 suggesting strong statistical support for the LE+k-means performance. Potential nonlinear structures in the data could be an explanation for this observation, see Figure 13.

From: Nonlinear gene cluster analysis with labeling for microarray gene expression data in organ development

 

k-means

PCA+k-means

LE+k-means

# enriched Go-categories

55

17

27

# enriched Go-categories specific to eye development

0

0

3