Skip to main content

Table 1 DoE performed with the BioProzessTrainer

From: “BioProzessTrainer” as training tool for design of experiments

   

cell conc. [ 108 cells/L]

antibody conc. [mg/L]

seed conc. [108 cells/L ]

glutamine [mmol/L]

glucose [mmol/L]

   

15

30

15

30

set

4.0

1

7.71

8.01

11.8

12.6

-10%

3.6

1

7.15

7.49

11.1

12.1

+10%

4.4

1

8.23

8.49

12.3

13.0

set

4.0

4

1.17

1.37

22.5

27.7

-10%

3.6

4

1.06

1.24

20.6

25.2

+10%

4.4

4

1.27

1.49

24.4

30.2

  1. Impact of glucose and glutamine concentration on cell density and antibody concentration