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Table 3 Genes significantly associated with disease liability for each ethnic group at the significance levels of 0.05 and 1.56 × 10−5

From: Identification of multiple rare variants associated with a disease

Africans (n = 215)

Europeans (n = 156)

Asians (n = 321)

Gene

Replicates significant at 0.05 (%)a

Replicates significant at 1.56 × 10−5 (%)b

Gene

Replicates significant at 0.05 (%)a

Replicates significant at 1.56 × 10−5 (%)b

Gene

Replicates significant at 0.05 (%)a

Replicates significant at 1.56 × 10−5 (%)b

CYSLTR2

84

71

CCNH

72

57

CHEK1

95.5

95.5

FER

77

50.5

CLPTM1

71

38

FLJ43860

72.5

64

FNDC3A

73

68

CYP17A1

74

65.5

IL4I1

74.5

53.5

NTRK1

71

59.5

GDNF

83

22

LRRC20

74.5

69.5

OR8J3

71.5

51.5

OR13A1

86.5

82.5

NF2

87.5

67.5

PTPN11

86.5

74

   

SPINK2

89.5

47

      

ST5

84.5

79.5

  1. Listed genes were significant in at least 70% of replicates. None of the genes were true causal genes in the simulation model. Analysis is for all SNPs.
  2. a Percentage of replicates in which the gene was significantly associated with disease liability at the significance level of 0.05.
  3. b Percentage of replicates in which the gene was significantly associated with disease liability at the significance level of 1.56 × 10−5.
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BMC Proceedings

ISSN: 1753-6561

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