Table 4 Power to detect causal genes (out of 35 genes) in the GAW17 simulation models using the combined sample
From: Identification of multiple rare variants associated with a disease
Trait | All SNPs (nonsynonymous and synonymous) | Nonsynonymous SNPs | ||||
|---|---|---|---|---|---|---|
|  | Gene | Power calculated at significance level 0.05 (%) | Power calculated at significance level 1.56 × 10−5 (%) | Gene | Power calculated at significance level 0.05 (%) | Power calculated at significance level 1.56 × 10−5 (%) |
Disease liability | FLT1 | 100 | 92 | PTK2 | 54.5 | 33.5 |
| Â | Â | Â | Â | FLT1 | 96.5 | 97.5 |
Q1 | FLT1 | 100 | 92 | FLT1 | 96.5 | 97.5 |
| Â | KDR | 56.5 | 0 | KDR | 54.5 | 0 |
Q2 | VNN1 | 46.5 | 0 | VNN1 | 62 | 0 |