Table 1 Power of identifying nine genes with simulated genetic association
Gene | Power | Number of causal SNPs/total SNPs | ||||
|---|---|---|---|---|---|---|
α = 0.05 | α = 0.001 | α = 0.0001 | All SNPs | MAF < 5% | MAF ≥ 5% | |
ARNT | 0.255 | 0 | 0 | 5/18 | 5/17 | 0/1 |
ELAVL4 | 0.01 | 0 | 0 | 2/10 | 2/8 | 0/2 |
FLT1 | 1 | 0.97 | 0.95 | 11/35 | 10/32 | 1/3 |
FLT4 | 0.135 | 0.01 | 0 | 2/10 | 2/10 | 0/0 |
HIF1A | 0.17 | 0 | 0 | 4/8 | 4/8 | 0/0 |
HIF3A | 0.09 | 0 | 0 | 3/21 | 3/17 | 0/4 |
KDR | 0.955 | 0.525 | 0.245 | 10/16 | 9/15 | 1/1 |
VEGFA | 0.225 | 0.005 | 0.005 | 1/6 | 1/6 | 0/0 |
VEGFC | 0.775 | 0 | 0 | 1/1 | 1/1 | 0/0 |