Identification of genes associated with complex traits by testing the genetic dissimilarity between individuals

BMC Proceedings

Table 2 Most significant genes correlated with Q1 and Affected

Trait	Gene	Chromosome	Gene start (bp)	Gene end (bp)	Gene length (bp)	Number of SNPs	Number of significant tests^a
Q1 (SNPs with MAF < 0.05)	FLT1	13	27774389	27967265	192877	32	49
	PIK3C3	18	37829928	37789197	126250	7	13
	KDR	4	55639406	55686519	47114	15	12
	PRR4	12	10889715	11215480	325766	17	11
Q1 (SNPs with MAF < 0.05)^b	FLT1	13	27774389	27967265	192877	32	39
Q1 (nonsynonymous SNPs with MAF < 0.05)^b	FLT1	13	27774389	27967265	192877	19	170
	KDR	4	55639406	55686519	47114	10	24
Affected (nonsynonymous SNPs with MAF < 0.05)	FLT1	13	27774389	27967265	192877	19	13

^a Number of significant tests out of 200 simulated data sets. The threshold of statistical significance is a Bonferroni-corrected p-value of 0.05 (1.74 × 10⁻⁵ for SNPs with MAF < 0.05 and 2.48 × 10⁻⁵ for nonsynonymous SNPs with MAF < 0.05).
^b Adjusted for Age, Sex, Smoke, and first two principal components.

ISSN: 1753-6561