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Table 2 Accuracy of estimates of β for trait Q1 between maximum-likelihood estimate (MLE) and hierarchical modeling (HM) estimates

From: Enhancing the discovery of rare disease variants through hierarchical modeling

Variable

Mean square error

Mean coverage ratea

 

MLE

HM

MLE

HM

C1S6521

0.196

0.046

0.68

0.94

C13S398

0.069

0.036

0.90

0.93

C13S515

0.300

0.029

0.07

0.92

C13S522

0.126

0.037

0.06

0.71

HFE, nonsynonymous

0.218

0.033

0.63

0.98

KCTD14, nonsynonymous

0.007

0.009

0.91

0.84

C4S1878

0.102

0.024

0.7

0.95

  1. a Proportion of replicates where true β falls within the 95% confidence interval.
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BMC Proceedings

ISSN: 1753-6561

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