Enhancing the discovery of rare disease variants through hierarchical modeling

BMC Proceedings

Table 5 Bayes factors for each causal variable under the Q2 trait model

Causal variable^a	UNINF	Z only	A only	FULL
C6S5441	53.96	77.22	65.32	88.21
SIRT1, nonsynonymous	22.36	34.60	23.92	34.82
C2S354	11.17	15.29	11.04	16.46
C8S442	62.14	88.72	64.60	87.26
C6S5449	64.43	85.17	73.89	94.77
SREBF1, nonsynonymous	60.71	83.47	60.57	85.76
PDGFD, nonsynonymous	49.64	71.03	49.12	70.54
C6S5426	0.87	1.48	1.25	2.10
C6S5380	212.1	264.3	210.2	263.0
PLAT, nonsynonymous	9.28	14.54	8.89	14.44
VLDLR, nonsynonymous	17.51	26.85	17.15	26.93
BCHE, nonsynonymous	38.11	55.60	37.50	55.62
LPL, nonsynonymous	1.34	2.43	1.62	2.63

^a Defined as either a bin of SNPs (shown with convention gene name and mutation class) or a single SNP. Only variables with MAF ≥ 0.01 were included for analyses.

ISSN: 1753-6561