Exploration and comparison of methods for combining population- and family-based genetic association using the Genetic Analysis Workshop 17 mini-exome

Table 1 Average empirical rejection rates

Method	Noncausal SNPs		Causal SNPs
	All	With SNPs from spurious genes removed	All
Chen and Lin	0.0388	0.0378	0.0269
Zhang et al.	0.0420	0.0408	0.0761
Zhu et al.	0.0551	0.0551	0.0556

Empirical rejection rates over the 200 replications for each method averaged over all SNPs (24,327 noncausal SNPs and 160 causal SNPs, 2 of which confer susceptibility through two different components of the latent disease susceptibility distribution). Removing SNPs from the spurious genes [25] results in 16,380 noncausal SNPs.

ISSN: 1753-6561