Figure 2
From: Prioritizing single-nucleotide variations that potentially regulate alternative splicing
Relationships between synonymous variations and their effects on the binding of RBPs (A) Hierarchical clustering of RBPs and 183 synonymous variations that can potentially affect binding of more than one RBP, based on their AC values (Eq. (1)); red and blue indicate potential gain and loss of binding in the minor alleles. (B) Principal components analysis (PCA) biplot with variations plotted against the top three principal components; nine RBPs show their similarity or dissimilarity with respect to the effects of variations on their binding affinity.