Skip to main content

Table 2 Power to identify each associated gene for trait D

From: Comparison of SNP-based and gene-based association studies in detecting rare variants using unrelated individuals

Gene

Observed FPR = 0.05

Observed FPR = 0.1

 

SNP

GL

GS

G2

SNP

GL

GS

G2

BCHE

0.155

0.12

0.005

0.195

0.375

0.25

0.04

0.285

FLT1

0.9

0.705

0.83

0.335

0.965

0.785

0.915

0.505

FLT4

0.14

0.17

0.005

0.2

0.2

0.26

0.01

0.37

HIF1A

0.1

0.13

0.015

0.16

0.185

0.22

0.03

0.335

KDR

0.2

0.42

0.06

0.41

0.645

0.585

0.12

0.585

LPL

0.255

0.04

0.075

0.055

0.4

0.095

0.145

0.135

HSP90AA1

0.11

0.035

0.025

0.06

0.305

0.075

0.09

0.075

PIK3C2B

0.37

0.085

0.095

0.105

0.665

0.2

0.21

0.175

PIK3C3

0.475

0.44

0.08

0.4

0.565

0.585

0.14

0.58

PRKCA

0.125

0.225

0.255

0.165

0.3

0.36

0.41

0.31

PTK2B

0.4

0.255

0.035

0.44

0.61

0.41

0.07

0.595

SOS2

0.24

0.09

0.29

0.145

0.375

0.205

0.415

0.3

VEGFC

0

0.275

0

0.26

0.05

0.385

0

0.335

VLDLR

0.19

0.05

0.02

0.065

0.32

0.085

0.06

0.115

VNN1

0.26

0.175

0.045

0.065

0.37

0.25

0.095

0.13

  1. SNP, GL, GS, and G2 are the SNP-based, gene-based linear, gene-based similarity, and gene-based two-step methods, respectively. The boldface values are the maximum power of these four methods.
Back to article page

BMC Proceedings

ISSN: 1753-6561

Contact us