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Table 2 Select >FLT1 SNPs in GAW17 exon sequencing data (replicate 137; unrelated individuals) and associations with Q1

From: Evaluating aggregate effects of rare and common variants in the 1000 Genomes Project exon sequencing data using latent variable structural equation modeling

SNP

Minor allele frequency

Crude model

Adjusted model 1a

Adjusted model 2b

Adjusted model 3c

Adjusted model 4d

  

β (SE)

p

β (SE)

p

β (SE)

p

β (SE)

p

β (SE)

p

C13S320

0.0014

1.18 (0.71)

0.0954

0.81 (0.67)

0.2227

0.78 (0.67)

0.2438

0.96 (0.65)

0.1375

0.96 (0.65)

0.1385

C13S399

0.0007

0.30 (1.00)

0.7676

0.13 (0.95)

0.8947

0.10 (0.95)

0.9145

−0.02 (0.92)

0.9819

−0.07(0.92)

0.9383

C13S431

0.0172

0.80 (0.21)

1.06 × 10−4

0.66 (0.19)

6.94 × 10-4

0.69 (0.20)

4.72 × 10−4

0.62 (0.22)

5.39 × 10−3

0.59 (0.22)

8.07 × 10−3

C13S458

0.0014

1.84 (0.71)

9.38 × 10−3

1.32 (0.67)

0.0490

1.29 (0.67)

0.0552

1.30 (0.65)

0.0465

1.32 (0.65)

0.0432

C13S479

0.0007

0.22 (1.00)

0.8263

0.39 (0.94)

0.6780

0.42 (0.94)

0.6546

0.29 (0.91)

0.7500

0.37 (0.91)

0.6821

C13S505

0.0007

−0.14 (1.00)

0.8926

0.25 (0.94)

0.7933

0.23 (0.95)

0.8094

0.34 (0.91)

0.7101

0.41 (0.92)

0.6583

C13S514

0.0007

1.03 (1.00)

0.3052

1.05 (0.94)

0.2660

1.08 (0.94)

0.2507

1.43 (0.91)

0.1173

1.43 (0.91)

0.1172

C13S522

0.0280

1.14 (0.16)

2.0 × 10−12

1.12 (0.15)

1.7 × 10−13

1.12 (0.15)

2.1 × 10−13

0.96 (0.16)

1.12 × 10−9

0.98 (0.16)

9.3 × 10−10

C13S523

0.0667

0.94 (0.11)

3.4 × 10−18

0.96 (0.10)

3.3 × 10−21

0.96 (0.10)

5.6 × 10−21

0.81 (0.12)

1.9 × 10−11

0.81 (0.12)

2.1 × 10−11

C13S524

0.0043

1.68 (0.41)

3.7 × 10−5

1.98 (0.38)

2.66 × 10−7

1.97 (0.38)

3.17 × 10−7

1.58 (0.38)

3.12 × 10−5

1.59 (0.38)

3.04 × 10−5

C13S547

0.0007

0.08 (1.00)

0.9330

0.54 (0.94)

0.5652

0.57 (0.95)

0.5457

0.70 (0.91)

0.4443

0.69 (0.91)

0.4501

C13S557

0.0072

0.92 (0.32)

3.63 × 10−3

0.90 (0.30)

2.78 × 10−3

0.89 (0.30)

2.97 × 10−3

0.69 (0.29)

0.0186

0.70 (0.29)

0.0171

C13S567

0.0007

0.43 (1.00)

0.6694

0.27 (0.94)

0.7758

0.29 (0.95)

0.7564

0.13 (0.92)

0.8837

0.15 (0.91)

0.8673

  1. a Adjusted for Age and Smoking.
  2. b Adjusted for Age, Smoking, Sex, and Pop1.
  3. c Adjusted for Age, Smoking, Sex, Pop1 and top 10 principal components (PCs).
  4. d Adjusted for Age, Smoking, Sex, Pop1 and top 12 PCs.