Figure 8
From: Methods for detecting associations between phenotype and aggregations of rare variants
Example of differing results from the three statistics. Histograms showing the frequency with which each SNP was included in the subset of SNPs on which the optimal score statistic was calculated, aggregated across all 200 replicates. Results are for the GA analysis of Q2 on chromosome 6. Results are for σLL (top), σMB (middle), and σME (bottom). The x-axis indexes the SNPs on chromosome 6 (each bar corresponds to a single SNP; bars are equally spaced for clarity). The y-axis shows the frequency with which the SNP was included in the optimal solution. Red x’s indicate positions of SNPs that are associated with the trait (according to GAW17 answers).