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Table 3 False positive rates of VSEA at a nominal significance level of 0.05 in step 2

From: Enrichment analysis of genetic association in genes and pathways by aggregating signals from both rare and common variants

  

Gene-based test

 

Method

CMC-1

CMC-count

WeightSum1

WeightSum2

Spurious genes present

GSEA

0.057

0.060

0.097

0.089

 

VSEA

<0.001

0.086

0.080

0.080

Spurious genes excluded

GSEA

0.047

0.047

0.056

0.070

 

VSEA

0.061

0.060

0.070

0.070

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BMC Proceedings

ISSN: 1753-6561

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