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Table 2 Type I error rates for Q1 and Q2 using all noncausal SNPs in noncausal genes

From: Principal components ancestry adjustment for Genetic Analysis Workshop 17 data

Model

MAF < 0.005

0.005 < MAF < 0.01

0.01 < MAF < 0.05

0.05 < MAF < 0.5

Total

 

D (%)

Q (%)

D (%)

Q (%)

D (%)

Q (%)

D (%)

Q (%)

D (%)

Q (%)

Q1

          

SNP

9.7

6.0

9.0

9.3

17.0

21.2

20.9

31.3

12.1

11.7

Population adjustment

9.1

5.8

9.0

8.5

16.3

17.9

20.0

23.6

11.5

10.0

PC adjustment

6.6

5.7

6.3

6.4

6.8

6.9

5.7

6.7

6.5

6.0

Q2

          

SNP

5.9

5.6

6.8

7.0

5.9

5.8

6.7

7.9

6.1

6.0

Population adjustment

6.1

5.6

7.7

7.1

5.9

5.6

5.6

5.7

6.2

5.7

PC adjustment

5.7

5.4

6.0

6.0

5.3

5.0

4.8

4.9

5.6

5.4

  1. D is the dichotomized phenotype; Q is the quantitative phenotype. Noncausal SNPs for Q1 come from chromosomes 12, 21, and 22. Noncausal SNPs for Q2 come from chromosomes 21 and 22. Nominal type I error rate = 0.05, 200 replicates.