Genetic signal maximization using environmental regression

BMC Proceedings

Table 2 Differences (Δ) in heritability and Χ² for the first – replicates in the GAW17 data

Replicate	ΔH2R^a Q1	ΔQ1 chi-square, all (n = 7,087)	ΔQ1 chi-square, true (n = 58)	ΔQ1 chi-square, Affected (n = 12)	ΔH2R^a Q2	ΔQ2 chi-square, all (n = 7,087)	ΔQ2 chi-square, true (n = 58)	ΔQ2 chi-square, Affected (n = 12)	ΔH2R^a Q4	ΔQ4 chi-square, all (n = 7,087)	ΔQ4 chi-square, true (n = 58)	ΔQ4 chi-square, Affected (n = 12)
1	−0.01	−0.182	−0.728	−0.368	0.07	−0.205	−0.335	0.028	−0.012	0.504	0.041	0.096
2	−0.014	−0.107	−0.335	0.028	0.004	−0.198	−0.028	0.0003	0.095	0.012	0.005	−0.005
3	0.154	−0.132	−0.262	0.171	0.241	−0.302	−0.255	0.334	0.018	−0.038	−0.083	−0.099

^a Differences in heritability between a measured genotype association model in which the β coefficient is allowed to vary and the model in which the β coefficient is constrained to the environmental correlation between Affected status and a quantitative trait.
n is the number of SNPs in each set tested.

ISSN: 1753-6561