Table 3 Power to detect the causal genes on the latent liability at the 0.05 significance level
From: Gene-based multiple trait analysis for exome sequencing data
Gene | Q1 | Q2 | Q4 | D | Q1+Q2 +Q4+D | OCMT | Subset with the highest power (power) |
|---|---|---|---|---|---|---|---|
AKT3 | 0.025 0.070 | 0.045 0.055 | 0.030 0.020 | 0.020 0.020 | 0.040 0.025 | 0.030 0.030 | Q4+D (0.040) Q1+D (0.045) |
BCL2L11 | 0.030 0.030 | 0.050 0.075 | 0.030 0.020 | 0.065 0.060 | 0.055 0.065 | 0.055 0.070 | Q1+Q2+D (0.080) Q2+D (0.095) |
ELAVL4 | 0.520 0.045 | 0.050 0.035 | 0.060 0.045 | 0.030 0.045 | 0.390 0.040 | 0.380 0.045 | Q1 +D (0.465) Q1+Q3 (0.055) |
HSP90AA1 | 0.065 0.010 | 0.050 0.055 | 0.080 0.040 | 0.075 0.030 | 0.095 0.035 | 0.095 0.045 | Q1+Q2+D (0.125) Q1+Q2+D (0.055) |
NRAS | 0.015 0.020 | 0.035 0.035 | 0.035 0.010 | 0.095 0.095 | 0.010 0.015 | 0.005 0.010 | Q4+D (0.045) Q4+D (0.045) |
PIK3C2B | 0.030 0.055 | 0.085 0.105 | 0.025 0.020 | 0.200 0.145 | 0.125 0.100 | 0.115 0.105 | Q1+D (0.190) Q1+D (0.145) |
PIK3C3 | 0.990 0.280 | 0.065 0.025 | 0.045 0.020 | 0.540 0.200 | 0.910 0.180 | 0.915 0.175 | Q1+Q4 (0.970) Q1+Q4+D (0.190) |
PRKCA | 0.480 0.025 | 0.045 0.045 | 0.045 0.010 | 0.395 0.115 | 0.310 0.080 | 0.355 0.080 | Q1+D (0.425) Q2+D (0.100) |
PRKCB1 | 0.025 0.045 | 0.055 0.060 | 0.035 0.035 | 0.035 0.025 | 0.030 0.045 | 0.045 0.040 | Q2+Q4+D (0.045) Q1+Q2+Q4+D (0.045) |
PTK2 | 0.660 0.095 | 0.075 0.025 | 0.020 0.015 | 0.160 0.050 | 0.405 0.035 | 0.400 0.060 | Q1+D (0.530) Q1+D (0.105) |
PTK2B | 1.000 0.190 | 0.235 0.020 | 0.040 0.055 | 0.525 0.090 | 0.990 0.135 | 0.995 0.130 | Q1+D (0.995) Q1+Q4+D (0.155) |
RRAS | 0.025 0.040 | 0.045 0.035 | 0.045 0.025 | 0.090 0.085 | 0.050 0.040 | 0.045 0.045 | Q2+Q4 (0.040) Q2+Q4 (0.280) |
SHC1 | 0.280 0.035 | 0.020 0.030 | 0.065 0.045 | 0.105 0.045 | 0.150 0.015 | 0.155 0.015 | Q1+Q2+D (0.065) Q2+D (0.090) |
SOS2 | 0.840 0.105 | 0.065 0.065 | 0.030 0.015 | 0.180 0.090 | 0.580 0.080 | 0.610 0.085 | Q1+D (0.745) Q1+Q2+D (0.105) |