Table 3 Observed p-values of causal genes in each tested approach and, when applicable, the genetic variant detected
Gene | A | B | C | D | E | F | G | H |
|---|---|---|---|---|---|---|---|---|
AKT3 | 0.52, NA −0.74 (0.16) | 0.52, NA −0.74 (0.16) | NCV | NCV | NCV | NCV | 1, NA NC (0.16) | 1, NA NC (0.16) |
BCL2L11 | 0.53, NA −0.21 (0.22) | 0.96, NA −0.02 (0.22) | 0.74, NA −0.03 (0.27) | 0.43, C2S2309 0.17 (0.27) | 1, NA NC (0.27) | 1, NA NC (0.27) | 1, NA NC (0.27) | 1, NA NC (0.27) |
ELAVL4 | 0.01*, NA −0.76 (0.21) | 0.98, NA −0.02 (0.21) | 0.28, NA −0.12 (0.30) | 0.01, C1S3201 0.46 (0.30) | 1, NA NC (0.30) | 1, NA NC (0.30) | 1, NA NC (0.30) | 1, NA NC (0.30) |
HSP90AA1 | 0.09, NA −0.30 (0.04) | 0.32, NA −0.41 (0.04) | 0.63, NA −0.06 (0.04) | 0.008, C14S3706 0.20 (0.04) | 0.29, C14S3706 −0.03 (0.04) | 0.21, C14S3706 −0.15 (0.04) | 1, NA NC (0.04) | 1, NA 0.14 (0.04) |
NRAS | 1, NA 0.00 (0.18) | 1, NA 0.00 (0.18) | NCV | NCV | NCV | NCV | 1, NA NC (0.18) | 1, NA NC (0.18) |
PIK3C2B | 0.61, NA 0.05 (0.18) | 0.69, NA −0.06 (0.18) | 0.45, NA 0.12 (0.30) | 0.0006, C1S9210 1.47 (0.30) | 1, NA NC (0.30) | 1, NA NC (0.30) | 0.01, C1S9183 0.13 (0.30) | 0.04, C1S9183 0.11 (0.30) |
PIK3C3 | 1, NA 0.00 (0.28) | 1, NA 0.00 (0.28) | 0.23, NA −0.63 (0.34) | 0.27, C18S2479 0.02 (0.34) | 1, NA NC (0.34) | 1, NA NC (0.34) | 1, NA NC (0.34) | 1, NA NC (0.34) |
PIK3R3 | 0.12, NA 5.16 (0.17) | 1, NA 0.00 (0.17) | 0.23, NA −0.11 (0.17) | 0.08, C1S2903 0.30 (0.17) | 0.005, C1S2903 0.02 (0.17) | 0.005, C1S2903 0.02 (0.17) | 0.003, C1S2864 0.15 (0.17) | 0.003, C1S2864 0.15 (0.17) |
PRKCA | 0.82, NA −0.21 (0.10) | 1, NA 0.00 (0.10) | 0.24, NA 0.11 (0.17) | 0.035, C17S3578 0.64 (0.17) | 0.15, C17S4567 0.04 (0.17) | 0.15, C17S4567 0.04 (0.17) | 1, NA NC (0.17) | 1, NA NC (0.17) |
PRKCB1 | 0.47, NA 0.15 (0.23) | 0.62, NA 0.27 (0.23) | 0.75, NA 0.02 (0.23) | 0.11, C16S1808 0.29 (0.23) | 1, NA NC (0.23) | 1, NA NC (0.23) | 1, NA NC (0.23) | 1, NA NC (0.23) |
PTK2 | 0.04, NA −1.62 (0.03) | 0.04, NA 0.27 (0.03) | 0.17, NA −0.28 (0.03) | 0.029, C8S4830 0.26 (0.03) | 1, NA NC (0.03) | 1, NA NC (0.03) | 1, NA NC (0.03) | 1, NA NC (0.03) |
PTK2B | 0.89, NA 0.08 (0.13) | 1, NA 0.00 (0.13) | 0.003, NA −0.22 (0.20) | 0.01, C8S911 −0.14 (0.20) | 0.001, C8S911 0.05 (0.20) | 0.001, C8S911 0.05 (0.20) | 1, NA NC (0.20) | 1, NA NC (0.20) |
RRAS | 0.41, NA −0.19 (0.17) | 0.61, NA −0.42 (0.17) | 0.33, NA 0.10 (0.20) | 0.08, C19S4940 0.07 (0.20) | 1, NA NC (0.20) | 1, NA NC (0.20) | 1, NA NC (0.20) | 1, NA NC (0.20) |
SHC1 | 0.71, NA −0.35 (0.09) | 1, NA 0.00 (0.09) | 0.15, NA −0.17 (0.09) | 0.03, C1S7055 0.00 (0.09) | 1, NA NC (0.09) | 1, NA NC (0.09) | 1, NA NC (0.09) | 1, NA NC (0.09) |
SOS2 | 1, NA 0.00 (0.25) | 1, NA 0.00 (0.25) | 0.008, NA −0.26 (0.28) | 0.009, C14136 −0.21 (0.28) | 1, NA NC (0.28) | 1, NA NC (0.28) | 1, NA NC (0.28) | 1, NA NC (0.28) |