Do rare variant genotypes predict common variant genotypes?

BMC Proceedings

Table 2 Significant regressions for family members

Rare or common variant type	N significant	N total	% significant
Nonsynonymous/nonsynonymous	136	312	43.6
Nonsynonymous/synonymous	137	362	37.8
Synonymous/nonsynonymous	119	271	43.9
Synonymous/synonymous	148	350	42.3

As in unrelated individuals, the number of nominally significant regressions did not differ significantly by variant functional type. However, the percentage of significant regressions was substantially higher for all functional classes than in unrelated individuals.

ISSN: 1753-6561