Do rare variant genotypes predict common variant genotypes?

BMC Proceedings

Table 3 Direct comparison of regression results in unrelated individuals and families

Locus	Common SNP	Number of rare SNPs	β, unrelated individuals	LRT, unrelated individuals	β, families	LRT, families
MKI67	C10S6822	6	0.11	3.43	0.15	3.88
WFDC3	C20S1341	4	−0.08	0.58	−0.18	7.67
LASS4	C19S921	2	−0.01	0.00	0.02	0.01
ZNF571	C19S3534	1	1.16	2.61	1.20	3.01

When the set of rare variants is the same in regression tests for both the unrelated individuals and the family members, evidence for correlation between the CVGS and the SRVGS is greater in the families. β = regression slope; LRT = likelihood ratio test statistic (distributed as a chi-square distribution with 1 degree of freedom).

ISSN: 1753-6561