Table 2 Empirical power of tests for genes in the VEGF pathway
From: Does pathway analysis make it easier for common variants to tag rare ones?
Gene | Number of SNPs | Empirical power | ||||
|---|---|---|---|---|---|---|
| Â | Total | Common | Rare | CMC | Weighted-sum | Weighted global test |
ARNT | 18 (5) | 3 (1) | 15 (4) | 0.31 | 0.28 | 0.12 |
ELAVL4 | 10 (2) | 3 (0) | 7 (2) | 0.27 | 0.10 | 0.14 |
FLT1 | 35 (11) | 10 (3) | 25 (8) | 0.80 | 0.83 | 0.84 |
FLT4 | 10 (2) | 2 (0) | 8 (2) | 0.03 | 0.02 | 0.02 |
HIF1A | 8 (4) | 1 (1) | 7 (3) | 0.03 | 0.02 | 0.03 |
HIF3A | 21 (3) | 6 (0) | 15 (3) | 0.13 | 0.04 | 0.15 |
KDR | 16 (10) | 2 (2) | 14 (8) | 0.16 | 0.09 | 0.08 |
VEGFA | 6 (1) | 1 (0) | 5 (1) | 0.07 | 0.05 | 0.08 |
VEGFC | 1 (1) | 0 (0) | 1 (1) | Â | Â | Â |