Table 1 Results of association testing on the first phenotype replicate
From: Search for compound heterozygous effects in exome sequence of unrelated subjects
| Â | Additive model, Beagle | Additive model, fastPHASE | Dominant model (no phase) | |||
|---|---|---|---|---|---|---|
Phenotype | Gene | p-value | Gene | p-value | Gene | p-value |
Affected | FLT1* | 2.21 × 10−6 | FLT1* | 1.04 × 10−6 | FLT1* | 3.75 × 10−6 |
|  | GRK4 | 1.25 × 10−4 | GRK4 | 1.49 × 10−4 | AHSA2 | 2.30 × 10−4 |
|  | AHSA2 | 2.30 × 10−4 | AHSA2 | 2.30 × 10−4 | B4GALT6 | 4.64 × 10−4 |
Q1 | FLT1* | 1.70 × 10−20 | FLT1* | 7.24 × 10−20 | FLT1* | 3.73 × 10−18 |
|  | ZNF550 | 3.63 × 10−4 | ZNF550 | 3.63 × 10−4 | ZNF502 | 1.37 × 10−4 |
|  | KIAA1542 | 7.05 × 10−4 | KIAA1542 | 7.15 × 10−4 | HNRPUL1 | 1.03 × 10−3 |
Q2 | VNN1* | 2.32 × 10−4 | SDPR | 3.84 × 10−4 | KRT9 | 8.67 × 10−4 |
|  | SDPR | 3.84 × 10−4 | VNN1* | 4.06 × 10−4 | SDPR | 8.87 × 10−4 |
|  | RUNX3 | 4.97 × 10−4 | RUNX3 | 4.97 × 10−4 | TRPV6 | 1.17 × 10−3 |
Q4 | GRIA4 | 1.18 × 10−4 | GRIA4 | 4.35 × 10−4 | GRIA4 | 1.18 × 10−4 |
|  | ABL1 | 2.81 × 10−4 | ABL1 | 2.81 × 10−4 | ABL1 | 2.81 × 10−4 |
|  | GRK4 | 4.16 × 10−4 | ICAM4 | 4.36 × 10−4 | SLC22A1 | 4.00 × 10−4 |