Table 1 Exemplary data of batch and fed batch cultivations under controlled (bioreactor) as well as uncontrolled (shaker) conditions
From: Introducing a new chemically defined medium and feed for hybridoma cell lines
| Â | Process | Maximum vcd [106 cells/mL] | IVCD [106 (cells*d)/mL] | Final mAb titer [mg/L] |
|---|---|---|---|---|
Shaker | Batch | 3.7 | 7.3 | 56.2 |
| Â | Fed batch | 10.5 | 39.5 | 447.5 |
Bioreactor | Batch | 3.7 | 9.52 | 61.0 |
| Â | Fed batch | 17.3 | 107.6 | 1035.4 |