Figure 1From: Incidence and potential causative factors associated with chronic benign neutropenia in the Kingdom of Saudi ArabiaMultipotent haematopoietic stem cell pathway associated with the production of different blood cell lineages. The highlighted gene in colour is associated with neutrophil production (SCF, TPO, G-CSF, IL-3, IL-5). These genes need to be investigated further to screen for any mutations that could result in an aberrant gene which could inhibit the synthesis of neutrophils leading to a lower neutrophil count. EPO (erythropoietin - cytokine), G-CSF (colony stimulating factor 3 (granulocyte) - cytokine), GM-CSF (colony stimulating factor 2 (granulocyte-macrophage) – cytokine), IL-15 (interleukin 15 – cytokine), IL-2 interleukin 2 – (cytokine), IL-3 interleukin 3 – (cytokine), IL-4 (interleukin 4 – (cytokine), IL-5 (IL-5 interleukin 5 – (cytokine), IL-7 (interleukin 7 – (cytokine), M-CSF colony stimulating factor 1 (macrophage) - cytokine, SCF (KIT ligand) – growth factor, TPO (thrombopoietin) – cytokine.Back to article page