Fig. 2

Genetic association between 3 phenotypes and homozygosity intensities, and gene expression regulation of DBP- and HTN-associated regions of HD on odd-numbered chromosomes. The results of homozygosity association tests for DBP (red line), SBP (blue line), and HTN (green line) are shown. The vertical axis represents the p values (−log₁₀ scale) of the homozygosity association tests after controlling for FDR. The horizontal axis represents the physical positions of the anchor SNVs of sliding windows by chromosome. The p values greater than the black reference line reflect statistical significance. Expression regulated by 1 DBP-associated and 2 HTN-associated regions of HD is shown in the 3 volcano plots, respectively. In each volcano plot, the vertical axis represents the p values (−log₁₀ scale) of generalized estimating equation analysis after controlling for FDR and the horizontal axis represents the fold change of gene expression. Genes with p values greater than the green reference line reflect statistical significance and are indicated by green triangles