Table 2 Type I errors (95Â % confidence intervals) of family-based sequence kernel association test in the family-based, population-based, and the combined data, and of meta-analytic approach
From: On combining family- and population-based sequencing data
Gene | Family | Population | Combined | Meta-analysis |
|---|---|---|---|---|
MAP4 | 0.050 (0.024–0.090) | 0.100 (0.062–0.150) | 0.085 (0.050–0.133) | 0.095 (0.058–0.144) |
TNN | 0.030 (0.011–0.064) | 0.080 (0.046–0.127) | 0.085 (0.050–0.133) | 0.125 (0.083–0.179) |
NRF1 | 0.050 (0.024–0.090) | 0.070 (0.039–0.115) | 0.080 (0.046–0.127) | 0.065 (0.035–0.109) |
LEPR | 0.040 (0.017–0.077) | 0.045 (0.021–0.084) | 0.080 (0.046–0.127) | 0.055 (0.028–0.096) |
FLT3 | 0.090 (0.054–0.139) | 0.060 (0.031–0.102) | 0.060 (0.031–0.102) | 0.070 (0.039–0.115) |
ZFP37 | 0.045 (0.021–0.084) | 0.045 (0.021–0.084) | 0.060 (0.031–0.102) | 0.110 (0.070–0.162) |
CGN | 0.040 (0.017–0.077) | 0.060 (0.031–0.102) | 0.070 (0.039–0.115) | 0.105 (0.066–0.156) |
MTRR | 0.035 (0.014–0.071) | 0.030 (0.011–0.064) | 0.065 (0.035–0.109) | 0.075 (0.043–0.121) |
SLC35E2 | 0.085 (0.050–0.133) | 0.065 (0.035–0.109) | 0.090 (0.054–0.139) | 0.100 (0.062–0.150) |
ZNF443 | 0.075 (0.043–0.121) | 0.060 (0.031–0.102) | 0.050 (0.024–0.090) | 0.070 (0.039–0.115) |
RAI1 | 0.035 (0.014–0.071) | 0.090 (0.054–0.139) | 0.080 (0.046–0.127) | 0.095 (0.058–0.144) |
PTTG1IP | 0.070 (0.039–0.115) | 0.080 (0.046–0.127) | 0.095 (0.058–0.144) | 0.110 (0.070–0.162) |
CABP2 | 0.055 (0.028–0.096) | 0.090 (0.054–0.139) | 0.090 (0.054–0.139) | 0.130 (0.087–0.185) |
ZNF544 | 0.045 (0.021–0.084) | 0.080 (0.046–0.127) | 0.090 (0.054–0.139) | 0.095 (0.058–0.144) |
REPIN1 | 0.065 (0.035–0.109) | 0.050 (0.024–0.090) | 0.075 (0.043–0.121) | 0.080 (0.046–0.127) |
GTF2IRD1 | 0.080 (0.046–0.127) | 0.075 (0.043–0.121) | 0.060 (0.031–0.102) | 0.080 (0.046–0.127) |
FLNB | 0.050 (0.024–0.090) | 0.070 (0.039–0.115) | 0.095 (0.058–0.144) | 0.120 (0.078–0.173) |
GSN | 0.065 (0.035–0.109) | 0.055 (0.028–0.096) | 0.055 (0.028–0.096) | 0.105 (0.066–0.156) |
LRP8 | 0.065 (0.035–0.109) | 0.050 (0.024–0.090) | 0.135 (0.091–0.190) | 0.105 (0.066–0.156) |
PSMD5 | 0.025 (0.008–0.057) | 0.080 (0.046–0.127) | 0.080 (0.046–0.127) | 0.090 (0.054–0.139) |
GAB2 | 0.030 (0.011–0.064) | 0.065 (0.035–0.109) | 0.065 (0.035–0.109) | 0.105 (0.066–0.156) |
ABTB1 | 0.075 (0.043–0.121) | 0.075 (0.043–0.121) | 0.100 (0.062–0.150) | 0.125 (0.083–0.179) |
KRTAD11-1 | 0.070 (0.039–0.115) | 0.055 (0.028–0.096) | 0.050 (0.024–0.090) | 0.055 (0.028–0.096) |