Fig. 3

The algorithm shows the steps and options to switch patients hospitalised for an acute coronary syndrome to the CV polypill strategy. Note: The coloured balls represent the appropriate formulation of the CNIC-Polypill according to the coloured lines of the algorithm. ^†Select P2Y12 inhibitor in addition to the CNIC-Polypill. *Dose adjusted to BP levels, previous ACEI/ARB dose and renal function. **Reassess in 3–4 weeks after discharge and readjust the dosage, consider adding A40 or ezetimibe and/or a PCSK9i. ^$Use only if the patient does not develop side effects to atorvastatin 80 mg (or equivalent doses of another statin). ACEI, angiotensin-converting enzyme inhibitor; ACS, acute coronary syndrome; ARB, angiotensin II receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; ASA, acetylsalicylic acid; AT, atorvastatin; BB, beta blocker; BP, blood pressure; DAPT, dual platelet therapy; EZE, ezetimibe; FDC, fixed-dose combination; LDL-c, low-density lipoprotein cholesterol; PCSK9i, proprotein convertase subtilisin/kexin type 9 inhibitor; RAM, ramipril; Tx, treatment. Source: Grigorian-Shamagian et al. Front Cardiovasc Med. 2021;8:663,361 [12]. Reproduced with permission