Volume 1 Supplement 1

Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci

Proceedings

Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci. Go to conference site.

St. Pete Beach, Florida, USA

11-15 November 2006

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  1. Proceedings

    Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits

    For Genetic Analysis Workshop 15 Problem 2, we organized data from several ongoing studies designed to identify genetic and environmental risk factors for rheumatoid arthritis. Data were derived from the North...

    Christopher I Amos, Wei Vivien Chen, Elaine Remmers, Katherine A Siminovitch, Michael F Seldin, Lindsey A Criswell, Annette T Lee, Sally John, Neil D Shephard, Jane Worthington, Francois Cornelis, Robert M Plenge, Ann B Begovich, Thomas D Dyer, Daniel L Kastner and Peter K Gregersen

    BMC Proceedings 2007 1(Suppl 1):S3

    Published on: 18 December 2007

  2. Proceedings

    Genetic Analysis Workshop 15: simulation of a complex genetic model for rheumatoid arthritis in nuclear families including a dense SNP map with linkage disequilibrium between marker loci and trait loci

    Data for Problem 3 of the Genetic Analysis Workshop 15 were generated by computer simulation in an attempt to mimic some of the genetic and epidemiological features of rheumatoid arthritis (RA) such as its pop...

    Michael B Miller, Gregg R Lind, Na Li and Soon-Young Jang

    BMC Proceedings 2007 1(Suppl 1):S4

    Published on: 18 December 2007

  3. Proceedings

    An empirical evaluation of the common disease-common variant hypothesis

    While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common variants of modest e...

    Gary K Chen, Eric Jorgenson and John S Witte

    BMC Proceedings 2007 1(Suppl 1):S5

    Published on: 18 December 2007

  4. Proceedings

    Comparison of tagging single-nucleotide polymorphism methods in association analyses

    Several methods to identify tagging single-nucleotide polymorphisms (SNPs) are in common use for genetic epidemiologic studies; however, there may be loss of information when using only a subset of SNPs. We so...

    Ellen L Goode, Brooke L Fridley, Zhifu Sun, Elizabeth J Atkinson, Alex S Nord, Shannon K McDonnell, Gail P Jarvik, Mariza de Andrade and Susan L Slager

    BMC Proceedings 2007 1(Suppl 1):S6

    Published on: 18 December 2007

  5. Proceedings

    Genetic association studies for gene expressions: permutation-based mutual information in a comparison with standard ANOVA and as a novel approach for feature selection

    Mutual information (MI) is a robust nonparametric statistical approach for identifying associations between genotypes and gene expression levels. Using the data of Problem 1 provided for the Genetic Analysis W...

    Silke Szymczak, Angelo Nuzzo, Christian Fuchsberger, Daniel F Schwarz, Andreas Ziegler, Riccardo Bellazzi and Bernd-Wolfgang Igl

    BMC Proceedings 2007 1(Suppl 1):S9

    Published on: 18 December 2007

  6. Proceedings

    Joint study of genetic regulators for expression traits related to breast cancer

    The mRNA expression levels of genes have been shown to have discriminating power for the classification of breast cancer. Studying the heritability of gene expression levels on breast cancer related transcript...

    Tian Zheng, Shuang Wang, Lei Cong, Yuejing Ding, Iuliana Ionita-Laza and Shaw-Hwa Lo

    BMC Proceedings 2007 1(Suppl 1):S10

    Published on: 18 December 2007

  7. Proceedings

    Multilocus analysis of GAW15 NARAC chromosome 18 case-control data

    The Genetic Analysis Workshop 15 rheumatoid arthritis data included a set of 460 cases and 460 controls genotyped at 2300 closely spaced markers on a 10 megabase region of chromosome 18q. We conducted a multil...

    Sharon R Browning and Jessica Thomas

    BMC Proceedings 2007 1(Suppl 1):S11

    Published on: 18 December 2007

  8. Proceedings

    Meta-genetic association of rheumatoid arthritis and PTPN22using PedGenie 2.1

    PedGenie beta version 2.1 is a unique, flexible, and easily implemented analysis software tool that is enhanced significantly by incorporation of meta-statistics to allow valid combined analysis of multiple st...

    Karen Curtin, Jathine Wong, Kristina Allen-Brady and Nicola J Camp

    BMC Proceedings 2007 1(Suppl 1):S12

    Published on: 18 December 2007

  9. Proceedings

    Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm

    Rheumatoid arthritis (RA, MIM 180300) is a common and complex inflammatory disorder. The North American Rheumatoid Arthritis Consortium (NARAC) data, as part of the Genetic Analysis Workshop 15 data, consists ...

    Yuejing Ding, Lei Cong, Iuliana Ionita-Laza, Shaw-Hwa Lo and Tian Zheng

    BMC Proceedings 2007 1(Suppl 1):S13

    Published on: 18 December 2007

  10. Proceedings

    Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis

    In the present paper, we used the North American Rheumatoid Arthritis Consortium data provided for Genetic Analysis Workshop 15 Problem 2 to: 1) estimate the penetrances of PTPN22 and HLA-DRB1 and, 2) test the...

    France Gagnon, David Hajage, Sabine Plancoulaine and Sophie Tezenas du Montcel

    BMC Proceedings 2007 1(Suppl 1):S14

    Published on: 18 December 2007

  11. Proceedings

    Association mapping of susceptibility loci for rheumatoid arthritis

    We analyzed a case-control data set for chromosome 18q from the Genetic Analysis Workshop 15 to detect susceptibility loci for rheumatoid arthritis (RA). A total number of 460 cases and 460 unaffected controls...

    Tai-Yue Kuo, Winston Lau, Cheng Hu and Weihua Zhang

    BMC Proceedings 2007 1(Suppl 1):S15

    Published on: 18 December 2007

  12. Proceedings

    Evaluating gene × gene and gene × smoking interaction in rheumatoid arthritis using candidate genes in GAW15

    We examined the potential gene × gene interactions and gene × smoking interactions in rheumatoid arthritis (RA) using the candidate gene data sets provided by Genetic Analysis Workshop 15 Problem 2. The multif...

    Ling Mei, Xiaohui Li, Kai Yang, Jinrui Cui, Belle Fang, Xiuqing Guo and Jerome I Rotter

    BMC Proceedings 2007 1(Suppl 1):S17

    Published on: 18 December 2007

  13. Proceedings

    Mapping a gene for rheumatoid arthritis on chromosome 18q21

    Although single chi-square analysis of the North American Rheumatoid Arthritis Consortium (NARAC) data identifies many single-nucleotide polymorphisms (SNPs) with p-values less than 0.05, none remain significant ...

    William Tapper, Andrew Collins and Newton E Morton

    BMC Proceedings 2007 1(Suppl 1):S18

    Published on: 18 December 2007

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