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  1. Klebsiella pneumoniae (K. pneumoniae) is a common cause of health-care associated infections (HAIs) and has high levels of antibiotic resistance. These bacteria are well-known for their ability to produce biofilm...

    Authors: Hera Nirwati, Kian Sinanjung, Fahrina Fahrunissa, Fernando Wijaya, Sarastia Napitupulu, Vania P. Hati, Mohamad S. Hakim, Andreanita Meliala, Abu T. Aman and Titik Nuryastuti
    Citation: BMC Proceedings 2019 13(Suppl 11):20

    This article is part of a Supplement: Volume 13 Supplement 11

  2. Keloids develop due to hyperactivity of keloid fibroblast (KF) in proliferation, migration, and collagen deposition along with low rates of collagen degradation. These are a result of the Wnt/Ī² catenin signali...

    Authors: Ishandono Dachlan, Yohanes Widodo Wirohadidjojo, Mae Sri Hartati Wahyuningsih, Teguh Aryandono, Hardyanto Soebono and Dwiki Afandy
    Citation: BMC Proceedings 2019 13(Suppl 11):14

    This article is part of a Supplement: Volume 13 Supplement 11

  3. Abdominal tuberculosis is an uncommon variant of extrapulmonary tuberculosis. It accounts for 3.5% of extrapulmonary tuberculosis. Diagnosis of abdominal tuberculosis is still a challenge due to its non-specif...

    Authors: Moh Nailul Fahmi and Annisaa Pelita Harti
    Citation: BMC Proceedings 2019 13(Suppl 11):13

    This article is part of a Supplement: Volume 13 Supplement 11

  4. Following publication of the original article [1], the authors reported the following author name error is the article:

    Authors: Olushayo Olu, Pamela Drameh-Avognon, Emil Asamoah-Odei, Francis Kasolo, Tomas Valdez, Grace Kabaniha, Humphrey Karamagi, Suvajee Good, Helena Oā€™Malley, Zabulon Yoti, Nirina Razakazoa, Etienne Minkoulou, Jean-Marie Dangou, Symplice Mbola Mbassi, Mariano Salazar Castellon, Joseph Cabore…
    Citation: BMC Proceedings 2019 13:11

    The original article was published in BMC Proceedings 2019 13:7

  5. The demography of Botswana is rapidly changing. Successes in tackling communicable diseases and economic development increased life expectancy from 53.7ā€‰years in 2006 to 66.8ā€‰years in 2016. The prevalence of d...

    Authors: Barbara Lachana Onen, Ciara Harris, Agnieszka Ignatowicz, Justine Davies, Michalis Drouvelis, Andrew Howes, Oathokwa Nkomazana, Churchill Lukwiya Onen, Elizabeth Sapey, Billy Tsima and Daniel Lasserson
    Citation: BMC Proceedings 2019 13(Suppl 10):8

    This article is part of a Supplement: Volume 13 Supplement 10

  6. Inadequate access to quality health care services due to weak health systems and recurrent public health emergencies are impediments to the attainment of Universal Health Coverage and health security in Africa...

    Authors: Olushayo Olu, Pamela Drameh-Avognon, Emil Asamoah-Odei, Francis Kasolo, Thomas Valdez, Grace Kabaniha, Humphrey Karamagi, Suvajee Good, Helena Oā€™Malley, Zabulon Yoti, Nirina Razakazoa, Etienne Minkoulou, Jean-Marie Dangou, Symplice Mbola Mbassi, Mariano Salazar Castellon, Joseph Cabore…
    Citation: BMC Proceedings 2019 13(Suppl 9):7

    This article is part of a Supplement: Volume 13 Supplement 9

    The Correction to this article has been published in BMC Proceedings 2019 13:11

  7. To address an urgent need to advance the field of community engaged research, faculty at Vanderbilt University Medical Center and Meharry Medical College organized the national meeting "Advancing the Science o...

    Authors: Al Richmond, Sergio Aguilar-Gaxiola, ElisƩo J. Perez-Stable, Usha Menon, Chanita Hughes-Halbert, Karriem S. Watson, Regina Greer-Smith, Courtney Clyatt, Jonathan N. Tobin and Consuelo H. Wilkins
    Citation: BMC Proceedings 2019 13(Suppl 3):3

    This article is part of a Supplement: Volume 13 Supplement 3

  8. Natural disasters such as earthquakes, typhoons, floods, and volcanic eruptions frequently occur in Republic of Philippines and mental health care for children affected by these natural disasters is a major pu...

    Authors: Masahide Usami, Marian Fe Theresa Lomboy, Naoko Satake, Crystal Amiel M. Estrada, Mitsuya Kodama, Ernesto R. Gregorio Jr, Yuriko Suzuki, Ramir B. Uytico, Minerva P. Molon, Ikuhiro Harada, Keita Yamamoto, Kumi Inazaki, Hirokage Ushijima, Cynthia Leynes, Jun Kobayashi, Romeo R. Quizon…
    Citation: BMC Proceedings 2018 12(Suppl 14):65

    This article is part of a Supplement: Volume 12 Supplement 14

  9. Primary ciliary dyskinesia (PCD) is a chronic suppurative airways disease that is usually recessively inherited and has marked clinical phenotypic heterogeneity. Classic symptoms include neonatal respiratory d...

    Authors: Hannah Farley, Bruna Rubbo, Zuzanna Bukowy-Bieryllo, Mahmoud Fassad, Myrofora Goutaki, Katharine Harman, Claire Hogg, Claudia E. Kuehni, Susana Lopes, Kim G. Nielsen, Dominic P. Norris, Ana Reula, Nisreen Rumman, Amelia Shoemark, Hannah Wilkins, Agatha Wisse…
    Citation: BMC Proceedings 2018 12(Suppl 16):64

    This article is part of a Supplement: Volume 12 Supplement 16

  10. Cholera remains a major public health problem in many countries. Poor sanitation and inappropriate clean water supply, insufficient health literacy and community mobilization, absence of national plans and cro...

    Authors: Mesbah Uddin Ahmed, Mario Baquilod, Claudio Deola, Nguyen Dong Tu, Dang Duc Anh, Cindy Grasso, Anu Gautam, Wan Mansor Hamzah, Seng Heng, Sopon Iamsirithaworn, Musal Kadim, S. K. Kar, Mai Le Thi Quynh, Anna Lena Lopez, Julia Lynch, Iqbal Memon…
    Citation: BMC Proceedings 2018 12(Suppl 13):62

    This article is part of a Supplement: Volume 12 Supplement 13

  11. The Genetic Analysis Workshop (GAW) presents an opportunity to collaboratively evaluate methodology relevant to current issues in genetic epidemiology. The GAW20 data combine real clinical trial data with fict...

    Authors: Elizabeth R. Piette and Jason H. Moore
    Citation: BMC Proceedings 2018 12(Suppl 9):59

    This article is part of a Supplement: Volume 12 Supplement 9

  12. In the search for an understanding of how genetic variation contributes to the heritability of common human disease, the potential role of epigenetic factors, such as methylation, is being explored with increa...

    Authors: Jenna Veenstra, Anya Kalsbeek, Karissa Koster, Nathan Ryder, Abbey Bos, Jordan Huisman, Lucas VanderBerg, Jason VanderWoude and Nathan L. Tintle
    Citation: BMC Proceedings 2018 12(Suppl 9):58

    This article is part of a Supplement: Volume 12 Supplement 9

  13. Statistical power, which is the probability of correctly rejecting a false null hypothesis, is a limitation of genome-wide association studies (GWAS). Sample size is a major component of statistical power that...

    Authors: Yuning Chen, Gina M. Peloso and JosƩe Dupuis
    Citation: BMC Proceedings 2018 12(Suppl 9):56

    This article is part of a Supplement: Volume 12 Supplement 9

  14. Genome-wide association studies often collect multiple phenotypes for complex diseases. Multivariate joint analyses have higher power to detect genetic variants compared with the marginal analysis of each phen...

    Authors: Xuan Deng, Biqi Wang, Virginia Fisher, Gina Peloso, Adrienne Cupples and Ching-Ti Liu
    Citation: BMC Proceedings 2018 12(Suppl 9):55

    This article is part of a Supplement: Volume 12 Supplement 9

  15. Because of the limited information from the GAW20 samples when only case-control or trio data are considered, we propose eLBL, an extension of the Logistic Bayesian LASSO (least absolute shrinkage and selectio...

    Authors: Xiaofei Zhou, Meng Wang, Han Zhang, William C. L. Stewart and Shili Lin
    Citation: BMC Proceedings 2018 12(Suppl 9):54

    This article is part of a Supplement: Volume 12 Supplement 9

  16. An increasing number of studies are focused on the epigenetic regulation of DNA to affect gene expression without modifications to the DNA sequence. Methylation plays an important role in shaping disease trait...

    Authors: Rui Sun, Haoyi Weng, Ruoting Men, Xiaoxuan Xia, Ka Chun Chong, William K. K. Wu, Benny Chung-Ying Zee and Maggie Haitian Wang
    Citation: BMC Proceedings 2018 12(Suppl 9):53

    This article is part of a Supplement: Volume 12 Supplement 9

  17. We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-feno...

    Authors: Juan M. Peralta, Nicholas B. Blackburn, Arthur Porto, John Blangero and Jac Charlesworth
    Citation: BMC Proceedings 2018 12(Suppl 9):52

    This article is part of a Supplement: Volume 12 Supplement 9

  18. Although methylation data continues to rise in popularity, much is still unknown about how to best analyze methylation data in genome-wide analysis contexts. Given continuing interest in gene-based tests for n...

    Authors: Jason Vander Woude, Jordan Huisman, Lucas Vander Berg, Jenna Veenstra, Abbey Bos, Anya Kalsbeek, Karissa Koster, Nathan Ryder and Nathan L. Tintle
    Citation: BMC Proceedings 2018 12(Suppl 9):50

    This article is part of a Supplement: Volume 12 Supplement 9

  19. Triglycerides are an important measure of heart health. Although more than 90 genes have been found to be associated to lipids, they only explain 12 to 15% of the variance in lipid levels. Evidence suggests th...

    Authors: Tony Huayang Gao, Jianjun Zhang, Diaz Medina Miguelangel and Xuexia Wang
    Citation: BMC Proceedings 2018 12(Suppl 9):49

    This article is part of a Supplement: Volume 12 Supplement 9

  20. Triglyceride (TG) concentrations decrease in response to fenofibrate treatment, and also are associated with DNA methylation. But how interactions between fenofibrate response and DNA methylation affect TGs re...

    Authors: Jih-Chang Yu, Fang-Chi Hsu and Yen-Feng Chiu
    Citation: BMC Proceedings 2018 12(Suppl 9):48

    This article is part of a Supplement: Volume 12 Supplement 9

  21. Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the l...

    Authors: Zheng Xu, Qing Duan, Juan Cui, Yumou Qiu, Qidong Jia, Cong Wu and Jennifer Clarke
    Citation: BMC Proceedings 2018 12(Suppl 9):46

    This article is part of a Supplement: Volume 12 Supplement 9

  22. Homozygosity disequilibrium (HD), indicating a nonrandom pattern of sizable runs of homozygosity that deviates from a random allocation of homozygous and heterozygous genotypes in the genome, is an important p...

    Authors: Hsin-Chou Yang and Chia-Wei Chen
    Citation: BMC Proceedings 2018 12(Suppl 9):45

    This article is part of a Supplement: Volume 12 Supplement 9

  23. The study of DNA methylation quantitative trait loci (meQTLs) helps dissect regulatory mechanisms underlying genetic associations of human diseases. In this study, we conducted the first genome-wide examinatio...

    Authors: Jiayi Wu Cox, Devanshi Patel, Jaeyoon Chung, Congcong Zhu, Samantha Lent, Virginia Fisher, Achilleas Pitsillides, Lindsay Farrer and Xiaoling Zhang
    Citation: BMC Proceedings 2018 12(Suppl 9):44

    This article is part of a Supplement: Volume 12 Supplement 9

  24. As part of GAW20, we analyzed the familiality and variability of methylation to identify cytosine-phosphate-guanine (CpG) sites responsive to treatment with fenofibrate. Methylation was measured at approximate...

    Authors: Rita Cantor, Linda Navarro and Calvin Pan
    Citation: BMC Proceedings 2018 12(Suppl 9):43

    This article is part of a Supplement: Volume 12 Supplement 9

  25. In this paper, a fully statistical investigation of the control of family structure as random effects is analyzed and discussed, using both the genome-wide association studies (GWAS) data and simulated data. T...

    Authors: Yayun Hsu, Jonathan Auerbach, Tian Zheng and Shaw-hwa Lo
    Citation: BMC Proceedings 2018 12(Suppl 9):42

    This article is part of a Supplement: Volume 12 Supplement 9

  26. In this paper we analyzed whole-genome genetic information provided by GAW20 from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study for family data. Lipid levels such as triglycerides (TGs) a...

    Authors: Sarmistha Das, Pronoy Kanti Mondal, Saurabh Ghosh and Indranil Mukhopadhyay
    Citation: BMC Proceedings 2018 12(Suppl 9):41

    This article is part of a Supplement: Volume 12 Supplement 9

  27. Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead...

    Authors: Hemant Kulkarni, Indranil Mukhopadhyay and Saurabh Ghosh
    Citation: BMC Proceedings 2018 12(Suppl 9):39

    This article is part of a Supplement: Volume 12 Supplement 9

  28. In a typical genome-enabled prediction problem there are many more predictor variables than response variables. This prohibits the application of multiple linear regression, because the unique ordinary least s...

    Authors: Svetlana Cherlin, Richard A. J. Howey and Heather J. Cordell
    Citation: BMC Proceedings 2018 12(Suppl 9):38

    This article is part of a Supplement: Volume 12 Supplement 9

  29. To examine whether single-nucleotide polymorphism (SNP) by methylation interactions can be detected, we analyzed GAW20 simulated triglycerides at visits 3 and 4 against baseline (visits 1 and 2) under 4 genera...

    Authors: E. Warwick Daw, James Hicks, Petra Lenzini, Shiow J. Lin, Judy Wang, Christine Williams, Ping An, Michael A. Province and Aldi T. Kraja
    Citation: BMC Proceedings 2018 12(Suppl 9):37

    This article is part of a Supplement: Volume 12 Supplement 9

  30. GAW20 provided participants with an opportunity to comprehensively examine genetic and epigenetic variation among related individuals in the context of drug treatment response. GAW20 used data from 188 families (

    Authors: Stella Aslibekyan, Laura Almasy, Michael A. Province, Devin M. Absher and Donna K. Arnett
    Citation: BMC Proceedings 2018 12(Suppl 9):35

    This article is part of a Supplement: Volume 12 Supplement 9

  31. The heritability of a phenotype is an estimation of the percent of variance in that phenotype that is attributable to additive genetic factors. Heritability is optimally estimated in family-based sample popula...

    Authors: Nicholas B. Blackburn, Arthur Porto, Juan M. Peralta and John Blangero
    Citation: BMC Proceedings 2018 12(Suppl 9):34

    This article is part of a Supplement: Volume 12 Supplement 9

  32. The main goal of this paper is to estimate the effect of triglyceride levels on methylation of cytosine-phosphate-guanine (CpG) sites in multiple-case families. These families are selected because they have 2 ...

    Authors: Angga M. Fuady, Renaud L. M. Tissier and Jeanine J. Houwing-Duistermaat
    Citation: BMC Proceedings 2018 12(Suppl 9):33

    This article is part of a Supplement: Volume 12 Supplement 9

  33. Using the real data set from GAW20, we examined changes in the distribution of DNA methylation before and after treatment. Paired analysis of differences in both mean and variance had grossly inflated type 1 e...

    Authors: Angelo J. Canty and Andrew D. Paterson
    Citation: BMC Proceedings 2018 12(Suppl 9):32

    This article is part of a Supplement: Volume 12 Supplement 9

  34. A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate genome-wide...

    Authors: Haakon E. Nustad, Christian M. Page, Andrew H. Reiner, Manuela Zucknick and Marissa LeBlanc
    Citation: BMC Proceedings 2018 12(Suppl 9):31

    This article is part of a Supplement: Volume 12 Supplement 9

  35. Epigenome association studies that test a large number of methylation sites suffer from stringent multiple-testing corrections. This studyā€™s goals were to investigate region-based associations between DNA meth...

    Authors: Kaiqiong Zhao, Lai Jiang, Kathleen Klein, Celia M. T. Greenwood and Karim Oualkacha
    Citation: BMC Proceedings 2018 12(Suppl 9):30

    This article is part of a Supplement: Volume 12 Supplement 9

  36. High-throughput platforms allow the characterization of thousands of previously known methylation sites. These platforms have great potential for investigating the epigenetic effects that are partially respons...

    Authors: Marcio Almeida, Juan Peralta, Jose Garcia, Vincent Diego, Harald Goring, Sarah Williams-Blangero and John Blangero
    Citation: BMC Proceedings 2018 12(Suppl 9):29

    This article is part of a Supplement: Volume 12 Supplement 9

  37. DNA methylation, an epigenetic modification, can be affected by environmental factors and thus regulate gene expression levels that can lead to alterations of certain phenotypes. Network analysis has been used...

    Authors: Elise Lim, Hanfei Xu, Peitao Wu, Daniel Posner, Jiayi Wu, Gina M. Peloso, Achilleas N. Pitsillides, Anita L. DeStefano, L. Adrienne Cupples and Ching-Ti Liu
    Citation: BMC Proceedings 2018 12(Suppl 9):27

    This article is part of a Supplement: Volume 12 Supplement 9

  38. Even though there has been great success in identifying lipid-associated single-nucleotide polymorphisms (SNPs), the mechanisms through which the SNPs act on each trait are poorly understood. The emergence of ...

    Authors: Anne E. Justice, Annie Green Howard, Lindsay FernƔndez-Rhodes, Misa Graff, Ran Tao and Kari E. North
    Citation: BMC Proceedings 2018 12(Suppl 9):22

    This article is part of a Supplement: Volume 12 Supplement 9

  39. Epigenetic modification has an effect on gene expression under the environmental alteration, but it does not change corresponding genome sequence. DNA methylation (DNAm) is one of the important epigenetic mech...

    Authors: Md. Mohaiminul Islam, Ye Tian, Yan Cheng, Yang Wang and Pingzhao Hu
    Citation: BMC Proceedings 2018 12(Suppl 9):21

    This article is part of a Supplement: Volume 12 Supplement 9

  40. Using data on 680 patients from the GAW20 real data set, we conducted Mendelian randomization (MR) studies to explore the causal relationships between methylation levels at selected probes (cytosine-phosphate-...

    Authors: Lai Jiang, Kaiqiong Zhao, Kathleen Klein, Angelo J. Canty, Karim Oualkacha and Celia M. T. Greenwood
    Citation: BMC Proceedings 2018 12(Suppl 9):20

    This article is part of a Supplement: Volume 12 Supplement 9

  41. Bayesian networks have been proposed as a way to identify possible causal relationships between measured variables based on their conditional dependencies and independencies. We explored the use of Bayesian ne...

    Authors: Richard A. J. Howey and Heather J. Cordell
    Citation: BMC Proceedings 2018 12(Suppl 9):19

    This article is part of a Supplement: Volume 12 Supplement 9

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