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Table 2 Parametric and Non-parametric linkage analysis under the best fitted model

From: A genome-wide ordered-subset linkage analysis for rheumatoid arthritis

    

Penetrancea

       

Covariate

Chr. no.

No. ordered subset families

Disease allele frequency

f1

f2

f3

Position (cM) of peak MOD score

Peak MOD score

HLOD (α)

NPL score

p-Value

Position of peak MOD for ASM

Nonparametric LOD

Age of Onset

4

472

0.19

0.01

0.015

0.1

46.74

6.1

6.14 (0.89)

4.56

0.000002

96.27

6.03

 

9

27

0.03

0

0.08

1

6.6

3.41

3.41 (0.99)

2.85

0.002

4.93

2.91

Anti-CCP level

2

219

0.18

0.01

0.015

0.1

151.68

4.09

4.08 (0.96)

3.72

0.0001

156.45

4.03

 

18

40

0.13

0

0.99

1

24.69

5.44

5.44 (0.99)

3.81

0.00008

24.69

5.03

 

19

10

0.07

0

0

0.04

52

3.32

3.32 (0.99)

3.28

0.0003

51.13

2.29

  1. af1, penetrance of wild-type homozygous; f2, penetrance of heterozygous; f3, penetrance of mutant homozygous