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Table 2 Parametric and Non-parametric linkage analysis under the best fitted model

From: A genome-wide ordered-subset linkage analysis for rheumatoid arthritis

     Penetrancea        
Covariate Chr. no. No. ordered subset families Disease allele frequency f1 f2 f3 Position (cM) of peak MOD score Peak MOD score HLOD (α) NPL score p-Value Position of peak MOD for ASM Nonparametric LOD
Age of Onset 4 472 0.19 0.01 0.015 0.1 46.74 6.1 6.14 (0.89) 4.56 0.000002 96.27 6.03
  9 27 0.03 0 0.08 1 6.6 3.41 3.41 (0.99) 2.85 0.002 4.93 2.91
Anti-CCP level 2 219 0.18 0.01 0.015 0.1 151.68 4.09 4.08 (0.96) 3.72 0.0001 156.45 4.03
  18 40 0.13 0 0.99 1 24.69 5.44 5.44 (0.99) 3.81 0.00008 24.69 5.03
  19 10 0.07 0 0 0.04 52 3.32 3.32 (0.99) 3.28 0.0003 51.13 2.29
  1. af1, penetrance of wild-type homozygous; f2, penetrance of heterozygous; f3, penetrance of mutant homozygous