Table 2 Two-locus models for the pooled data: NARAC, Canada-Illumina, France, and the first screen of UK
From: One- and two-locus models for mapping rheumatoid arthritis-susceptibility genes on chromosome 6
Type of analysis and ARPs | No. ARP | Estimate (95% CI) for | |||
|---|---|---|---|---|---|
τ1 (cM) | τ2 (cM) | λ 1 | λ 2 | ||
Unconstrained model | |||||
Full siblings | 1292 | 1.6 (1.4–1.8) | 1.2 (1.0–1.3) | ||
Half siblings | 45 | 1.8 (0.4–3.2) | 1.6 (0.6–2.6) | ||
Avuncular pairs | 84 | 1.1 (0.5–1.7) | 1.3 (0.3–2.3) | ||
Common τ1, τ2 | 51.3 (48.4–54.3) | 79.2 (61.9–96.5) | |||
Constrained model | 1421 | 49.1 (45.6–52.7) | 62.2 (54.7–69.6) | 1.5 (1.3–1.7) | 1.4 (1.3–1.6) |