From: One- and two-locus models for mapping rheumatoid arthritis-susceptibility genes on chromosome 6
Type of analysis and ARPs | No. ARP | Estimate (95% CI) for | |||
---|---|---|---|---|---|
τ1 (cM) | τ2 (cM) | λ 1 | λ 2 | ||
NARAC | |||||
Full siblings | 877 | 51.8 (48.6–54.9) | 84.3 (63.2–105.5) | 1.8 (1.4–2.1) | 1.2 (1.0–1.4) |
Half siblings | 45 | 18.2 (8.8–27.6) | 74.2 (58.8–89.6) | 2.3 (0.6–4.0) | 1.8 (0.6–3.0) |
Avuncular pairs | 84 | 8.7 (0.0–17.9) | 79.8 (57.8–101.8) | 1.6 (0.9–2.4) | 1.3 (0.2–2.4) |
Canada | |||||
Full siblings | 59 | 44.1 (29.8–58.4) | 156.3 (142.8–169.8) | 1.5 (0.5–2.5) | 1.7 (0.6–2.8) |
France | |||||
Full siblings | 119 | 44.9 (33.2–56.7) | NAa | 1.7 (0.7–2.6) | NA |
UK-Screen 1 | |||||
Full siblings | 237 | 52.5 (42.8–62.2) | NA | 1.5 (1.0–1.9) | NA |