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Table 1 99% confidence intervals (CIs) from various proceduresa

From: A likelihood-based procedure for obtaining confidence intervals of disease loci with general pedigree data

    GLRT/Asymptotic  
Pop. Modelsb (P A , f aa , f Aa , f AA ) LOD/Integrated With MA Without MA 3-LOD
FR FR1 11.36* 5.29* 5.71*  
  (0.05, 0.031, 0.045, 0.810) (42.10, 63.00) (43.46, 48.75) (43.45, 49.16) Null
  FR2 18.85* 11 modelsc 5.70*  
  (0.08, 0.030, 0.033, 0.523) (40.75, 63.55)   (43.13, 48.83) Null
  NARAC1 18.28*   14.84*  
  (0.10, 0.032, 0.276, 0.920) (41.55, 70.87)   (41.41, 62.59) Null
  NARAC2 19.33*   12.36*  
  (0.15, 0.020, 0.216, 0.695) (40.75, 63.55)   (41.36, 61.41) Null
NARAC NARAC1 12.78 12.50* 13.10* 24.16*
  (0.10, 0.032, 0.276, 0.920) (35.76, 57.96) (36.21, 52.56) (35.87, 52.76) (34.02, 58.18)
  NARAC2 20.23* 38 modelsc 11.97* 22.82*
  (0.15, 0.020, 0.216, 0.695) (34.98, 60.62)   (36.39, 52.36) (34.44, 57.26)
  FR1    5.46 12.88
  (0.05, 0.031, 0.045, 0.810) Null   (35.20, 40.66) (28.90, 41.78)
  FR2    5.85 19.04
  (0.08, 0.030, 0.033, 0.523) Null   (35.01, 40.86) (29.50, 52.17)
UK UK1 50.56* 27.65* 27.47* 40.18*
  (0.12, 0.014, 0.093, 0.504) (34.20, 87.58) (43.06, 72.51) (41.60, 69.07) (38.68, 78.86)
  UK2 19.47 15 modelsc 26.27* 38.54*
  (0.09, 0.025, 0.065, 0.830) (58.83, 78.58)   (44.59, 74.04) (40.58, 79.12)
  1. aFor each model and method, we give the length of the confidence set in cM, with a "*" to signify those that contain the HLA*DRB1 locus. We also provide the convex set of the confidence set below the length. For the GLRT/asymptotic procedure with MA, the number of models accounted for is also provided, below the convex set. The 3-LOD intervals are treated as approximate 99% CI [2].
  2. bModels {FR1, FR2}, {NARAC1, NARAC2} and {UK1, UK2} are the models consistent with IBD estimates for the FR, NARAC, and UK data, respectively. A is the disease allele and a the normal allele.
  3. cModels for GLRT/MA are inferred from the IBD estimates at the trait locus and their perturbations. They included the models explained in footnote b for individual analysis.
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BMC Proceedings

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