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Table 2 Maximum L-scores and positions on each chromosome for expression phenotypes selected for LOD score >3, selected at random, and simulated null data

From: The feasibility of oligogenic combined segregation and linkage analysis in CEPH pedigrees

 

Trait

 

202546_at (h2 = 0.399; p = 0.1468)a

 

204418_x_at (h2 = 0.420; p = 0.1439)

 

33307_at (h2 = 0.383; p = 0.0002)

 

218264_at (h2 = 0.161; p = 0.0063)

 

Simulated

Chr

Position (cM)b

L-score

Position (cM)

L-score

Position (cM)

L-score

Position (cM)

L-score

L-score

1

--

0.5

142.6c, d

477.7

--

3.6

--

1.2

0.8

2

115.5c, d

125.9

--

3.8

--

2.1

--

3.9

0.5

3

--

0.5

--e

1.0

25.5

19.1

39.5

17.6

0.5

4

--

0.5

--

1.9

--

3.2

--

2.2

0.5

5

--

0.5

--

1.1

--

2.5

--

4.7

0.8

6

--

0.5

--

0.8

--

1.4

--

6.6

0.4

7

--

1.7

--f

0.5

--

4.5

--

1.3

1.2

8

--

0.4

--

1.4

--

3.2

--

3.5

1.2

9

--

0.4

--e

0.5

--f

2.1

--

9.4

1.0

10

--

0.6

--

0.8

--

1.4

--c

1.1

0.9

11

--

0.4

--

0.9

--

1.4

46.5e

16.5

1.5

12

--

0.8

--

0.3

--

4.3

--

2.1

0.6

13

--

0.5

--

0.6

--

5.9

--

2.7

0.5

14

--

0.4

--e

1.8

--

1.6

--

2.1

0.6

15

--

0.4

--

0.7

--

2.0

--

1.9

0.4

16

--

0.5

--

0.4

--

0.7

--

1.1

1.1

17

--

0.5

--

0.6

--

0.7

--

2.7

0.7

18

--

0.4

--

0.3

--

1.2

--

1.6

0.5

19

--

0.4

--

1.3

--

0.5

5.1

9.7

0.5

20

--

0.4

--

0.4

--

0.7

--

0.9

0.4

21

--

0.5

--

0.8

--

2.2

--

6.0

0.7

22

--

0.5

--

0.6

61.5c, d

163.2

--

1.9

0.5

  1. aSharpiro-Wilk normal test p-value
  2. b--, L-scores <7.3
  3. cChromosome with structural gene
  4. dLOD > 3
  5. e2 > LOD > 1.5
  6. f3 > LOD > 2