Rheumatoid arthritis, item response theory, Blom transformation, and mixed models

Kraja, Aldi T; Corbett, Jon; Ping, An; Lin, Rosa S; Jacobsen, Petra A; Crosswhite, Michael; Borecki, Ingrid B; Province, Michael A

doi:10.1186/1753-6561-1-S1-S116

BMC Proceedings

Table 1 NARAC data, additive model p-values and effects for the anti-CCP Blom-transformed and the IRT latent variable data^a

From: Rheumatoid arthritis, item response theory, Blom transformation, and mixed models

	Anti-CCP Blom-transformed					IRT latent variable
No.	SNP	p-value	Additive effect	STD	bp	SNP	p-value	Additive effect	STD	bp
1	rs189512	0.00067	-0.14680	0.04294	6923632	rs2876143	0.00816	0.07944	0.02993	8928623
2	rs214527	0.01890	-0.11800	0.05014	18399329	rs1863995	0.04430	-0.05370	0.02665	13565596
3	rs1402405	0.02528	0.08417	0.03755	24198476	rs736794	0.04758	-0.04813	0.02425	41044688
4	rs1224485	0.02145	0.08928	0.03874	37043628	rs1009130	0.00301	0.08090	0.02716	58068726
5	rs1738240	0.01339	0.10040	0.04051	38810588	rs977382	0.02981	0.06241	0.02866	62057200
6	rs533393	0.00897	-0.10350	0.03951	81645240	rs1040802	0.01273	-0.06005	0.02403	63469278
7	rs1180237	0.01758	0.09720	0.04085	83939524	rs2076874	0.00397	0.06580	0.02276	64150527
8	rs910563 ^b	0.01025	0.10250	0.03983	88054481	rs1630182	0.02261	-0.05252	0.02298	64205048
9	rs1051131	0.04853	0.07951	0.04024	88217142	rs1370436	0.03343	0.05014	0.02352	74520012
10	rs2144363	0.02680	0.19480	0.08778	92037502	rs910563	0.03853	0.04794	0.02312	88054481
11	rs6454855	0.04535	0.07830	0.03906	92071536	rs2610715	0.01464	-0.05937	0.02425	89260502
12	rs716192	0.04829	-0.08171	0.04131	96557287	rs240153	0.04093	-0.04727	0.02307	101112733
13	rs1321807	0.02545	0.08678	0.03876	117730562	rs239229	0.02728	-0.05129	0.02318	101151573
14	rs941815	0.04541	-0.08273	0.04128	123901148	rs239189	0.03231	0.04970	0.02317	101174385
15	rs839556	0.04100	0.08086	0.03950	142852448	rs1158747	0.03314	-0.05161	0.02417	112546220
16	rs923459	0.00991	0.10150	0.03927	159471138	rs763075	0.00505	0.06554	0.02330	122192096
17	rs294882	0.02322	-0.09232	0.04059	159512287	rs1033540	0.04603	-0.04924	0.02463	131717872
18						rs225604	0.00643	0.06488	0.02373	142433136
19						rs1931992	0.00209	0.07516	0.02433	142581777
20						rs2151913	0.03291	-0.05082	0.02377	150161633
21						rs718527	0.01903	-0.05770	0.02454	152501127
22						rs231958	0.01449	0.06105	0.02490	155786394
23						rs923459	0.01838	0.05568	0.02356	159471138
24						rs409359	0.04983	-0.04526	0.02303	159854284
25						rs916331	0.01358	0.05892	0.02380	167379847

^aSee the Discussion paragraph for details on the genes that have significant SNPs part of this study. bBold text indicates significant SNPs replicated in the association tests for two different RA outcomes.

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ISSN: 1753-6561

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