Table 1 Heritability (h2), association testing (minimum p-values of SNP and haplotype association test), and linkage analysis (maximum LOD scores)a
From: Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules
NFKB1 (106 SNPs) | NFKB2 (3 SNPs) | REL (16 SNPs) | RELA (3 SNPs) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Probe | h 2 | h2 p-Value | SNP | Haplotype | LOD | SNP | Haplotype | LOD | SNP | Haplotype | LOD | SNP | Haplotype | LOD |
BCL2A1 | 205681_at | 0.42 | 0.0008 | 0.029 | 0.040 | <1.00 | 0.04 | >0.05 | <1.00 | >0.05 | >0.05 | 1.70 | >0.05 | >0.05 | 1.61 |
BIRC2 | 202076_at | 0.48 | 0.0003 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | 1.24 |
CD40 | 35150_at | 0.49 | 0.0003 | >0.05 | >0.05 | <1.00 | 0.01 | >0.05 | <1.00 | 0.28 | 0.047 | 2.17 | >0.05 | >0.05 | 1.31 |
CD44 | 204490_s_at | 0.46 | 0.0004 | 0.034 | 0.009 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
CD80 | 207176_s_at | 0.49 | 0.0003 | 0.025 | 0.017 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
CFLAR | 211317_s_at | 0.48 | 0.0003 | >0.05 | >0.05 | <1.00 | 0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
CR2 | 205544_s_at | 0.47 | 0.0003 | >0.05 | >0.05 | <1.00 | 0.02 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
FAS | 204780_s_at | 0.43 | 0.0007 | 0.032 | >0.05 | 1.38 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
ICAM1 | 202638_s_at | 0.46 | 0.0004 | 0.025 | 0.05 | <1.00 | 0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
IL15 | 205992_s_at | 0.41 | 0.0009 | 0.013 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | 0.038 | 0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
IRF1 | 202531_at | 0.42 | 0.0009 | 0.031 | 0.022 | 2.54 | >0.05 | >0.05 | 1.45 | 0.01 | 0.05 | <1.00 | >0.05 | >0.05 | <1.00 |
JUNB | 201473_at | 0.41 | 0.0009 | 0.033 | >0.05 | <1.00 | 0.01 | >0.05 | <1.00 | 0.0082 | 0.016 | <1.00 | >0.05 | >0.05 | <1.00 |
MYC | 202431_s_at | 0.51 | 0.0002 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | <1.00 | >0.05 | >0.05 | 1.37 | >0.05 | >0.05 | <1.00 |
SLC2A5 | 204429_s_at | 0.47 | 0.0003 | >0.05 | >0.05 | <1.00 | 0.03 | >0.05 | 1.01 | 0.02 | 0.002 | <1.00 | >0.05 | >0.05 | <1.00 |
VCAM1 | 203886_s_at | 0.43 | 0.0007 | 0.011 | 0.010 | <1.00 | >0.05 | >0.05 | <1.00 | 0.01 | 0.048 | <1.00 | >0.05 | >0.05 | <1.00 |