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Table 2 Linkage analysis and family-based association tests (FBAT) using GAW15 data

From: Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules

 

Linkage analysis

FBAT (p < 0.05)

Gene

Max LOD (cM)

cM LOD > 1

SNPsa

Haplotypesa

NFKB1 (chromosome 4)

   FAS

1.38 (101.0)

97.4–106.8

rs721412

rs765220-rs971696-rs721412

   IRF1

2.54 (106.7)

94.0–109.0

 

rs971696-rs721412-rs1557803

NFKB2 (chromosome 10)

   IRF1

1.45 (102.1)

100.0–112.0

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   SLC2A5

1.01 (97.5)

97.5–98.2

  

REL (chromosome 2)

   CD40

2.17 (70.2)

62.4–73.7

rs1363062

rs1520446-rs1974771-rs1363062

   BCL2A1

1.70 (70.2)

67.0–73.7

rs1106577

rs1177274-rs2167564-rs1106577

   MYC

1.37 (47.7)

45.0–50.0

 

rs2167564-rs1106577-rs2216924

RELA (chromosome 4)

   CD40

1.31 (60.6)

60.6–62.4

rs1867791

rs1966864-rs1993205-rs1867791

   BCL2A1

1.61 (60.8)

60.6–65.1

 

rs1867791-rs999297-rs175110

   BIRC2

1.24 (61.0)

60.6–63.8

  

RELB (chromosome 19)

   FAS

0.66 (58.0)

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  1. aFor each gene, SNPs and haplotypes were the same for all the phenotypes shown.