Skip to main content

Table 2 Linkage analysis and family-based association tests (FBAT) using GAW15 data

From: Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules

  Linkage analysis FBAT (p < 0.05)
Gene Max LOD (cM) cM LOD > 1 SNPsa Haplotypesa
NFKB1 (chromosome 4)
   FAS 1.38 (101.0) 97.4–106.8 rs721412 rs765220-rs971696-rs721412
   IRF1 2.54 (106.7) 94.0–109.0   rs971696-rs721412-rs1557803
NFKB2 (chromosome 10)
   IRF1 1.45 (102.1) 100.0–112.0 --- ---
   SLC2A5 1.01 (97.5) 97.5–98.2   
REL (chromosome 2)
   CD40 2.17 (70.2) 62.4–73.7 rs1363062 rs1520446-rs1974771-rs1363062
   BCL2A1 1.70 (70.2) 67.0–73.7 rs1106577 rs1177274-rs2167564-rs1106577
   MYC 1.37 (47.7) 45.0–50.0   rs2167564-rs1106577-rs2216924
RELA (chromosome 4)
   CD40 1.31 (60.6) 60.6–62.4 rs1867791 rs1966864-rs1993205-rs1867791
   BCL2A1 1.61 (60.8) 60.6–65.1   rs1867791-rs999297-rs175110
   BIRC2 1.24 (61.0) 60.6–63.8   
RELB (chromosome 19)
   FAS 0.66 (58.0) --- --- ---
  1. aFor each gene, SNPs and haplotypes were the same for all the phenotypes shown.